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利用蛹虫草素和蛹虫草提取物增强癌症免疫疗法，以增敏癌细胞并调节免疫反应。

Enhancing cancer immunotherapy using cordycepin and Cordyceps militaris extract to sensitize cancer cells and modulate immune responses.

机构信息

Unit of Excellence on Research and Development of Cancer Therapy, University of Phayao, Phayao, Thailand.

Division of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, Thailand.

出版信息

Sci Rep. 2024 Sep 19;14(1):21907. doi: 10.1038/s41598-024-72833-x.

DOI:10.1038/s41598-024-72833-x
PMID:39300166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11413023/
Abstract

Integrating immunotherapy with natural compounds holds promise in enhancing the immune system's ability to eliminate cancer cells. Cordyceps militaris, a traditional Chinese medicine, emerges as a promising candidate in this regard. This study investigates the effects of cordycepin and C. militaris ethanolic extract (Cm-EE) on sensitizing cancer cells and regulating immune responses against breast cancer (BC) and hepatocellular carcinoma (HCC) cells. Cordycepin, pentostatin and adenosine were identified in Cm-EE. Cordycepin treatment decreased HLA-ABC-positive cells in pre-treated cancer cells, while Cm-EE increased NKG2D ligand and death receptor expression. Additionally, cordycepin enhanced NKG2D receptor and death ligand expression on CD3-negative effector immune cells, particularly on natural killer (NK) cells, while Cm-EE pre-treatment stimulated IL-2, IL-6, and IL-10 production. Co-culturing cancer cells with effector immune cells during cordycepin or Cm-EE incubation resulted in elevated cancer cell death. These findings highlight the potential of cordycepin and Cm-EE in improving the efficacy of cancer immunotherapy for BC and HCC.

摘要

将免疫疗法与天然化合物相结合有望增强免疫系统消除癌细胞的能力。蛹虫草作为一种传统中药，在这方面具有很大的应用潜力。本研究旨在探讨蛹虫草素和蛹虫草乙醇提取物（Cm-EE）对乳腺癌（BC）和肝癌（HCC）细胞的致敏作用以及对免疫反应的调节作用。在 Cm-EE 中鉴定出了蛹虫草素、戊二醛和腺苷。蛹虫草素处理可降低预处理癌细胞中 HLA-ABC 阳性细胞的数量，而 Cm-EE 则增加了 NKG2D 配体和死亡受体的表达。此外，蛹虫草素增强了 CD3-阴性效应免疫细胞（尤其是自然杀伤（NK）细胞）上的 NKG2D 受体和死亡配体的表达，而 Cm-EE 预处理则刺激了 IL-2、IL-6 和 IL-10 的产生。在蛹虫草素或 Cm-EE 孵育过程中，将癌细胞与效应免疫细胞共培养可导致癌细胞死亡增加。这些发现表明蛹虫草素和 Cm-EE 有可能提高 BC 和 HCC 的癌症免疫疗法的疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c05/11413023/4bf6e7525aad/41598_2024_72833_Fig8_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c05/11413023/4bf6e7525aad/41598_2024_72833_Fig8_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c05/11413023/20f0859f95dd/41598_2024_72833_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6c05/11413023/2efd12824fba/41598_2024_72833_Fig7_HTML.jpg
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PLoS One. 2023 Sep 8;18(9):e0291363. doi: 10.1371/journal.pone.0291363. eCollection 2023.
3
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Heliyon. 2024 Dec 26;11(2):e41418. doi: 10.1016/j.heliyon.2024.e41418. eCollection 2025 Jan 30.
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Biomed Pharmacother. 2023 Oct;166:115286. doi: 10.1016/j.biopha.2023.115286. Epub 2023 Aug 12.
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Antioxidants (Basel). 2023 Jun 12;12(6):1260. doi: 10.3390/antiox12061260.
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