Lee S S, Cha S, Lee R L
Department of Pathology, North Iowa Medical Center, Mason City 50401.
J Surg Oncol. 1989 Jun;41(2):81-5. doi: 10.1002/jso.2930410206.
The relationship between cholecystectomy and subsequent development of colon cancer was investigated in a case-control study of 165 patients with histologically proven adenocarcinoma of the colon. These patients were from a community in Iowa where incidence of colon cancer was considered to be higher than average in the United States. The relative risk of developing colon cancer after cholecystectomy was shown to be 2.11 (P = .009) for the entire series and 2.91 (P = .002) for the female group. There was a difference of frequency in developing colon cancer after cholecystectomy between the right- and left-sided colons; the relative risk of the right versus the left colon cancer was 2.31 (P = .019). The other factors, including blood group, red cell indices, obesity, serum cholesterol, colonic diverticula, and co-existence of hyperplastic or adenomatous polyp disclosed no significant relation to colon cancer developed after cholecystectomy.
在一项针对165例经组织学证实为结肠癌的病例对照研究中，对胆囊切除术与随后结肠癌发生之间的关系进行了调查。这些患者来自爱荷华州的一个社区，该社区的结肠癌发病率被认为高于美国平均水平。整个系列中，胆囊切除术后患结肠癌的相对风险为2.11（P = 0.009），女性组为2.91（P = 0.002）。胆囊切除术后右侧和左侧结肠发生结肠癌的频率存在差异；右侧结肠癌与左侧结肠癌的相对风险为2.31（P = 0.019）。其他因素，包括血型、红细胞指数、肥胖、血清胆固醇、结肠憩室以及增生性或腺瘤性息肉的共存，均未显示与胆囊切除术后发生的结肠癌有显著关系。
