Nielsen G P, Theodors A, Tulinius H, Sigvaldason H
Department of Medicine, St. Joseph's Hospital, Hafnarfjordur, Iceland.
Am J Gastroenterol. 1991 Oct;86(10):1486-90.
The relationship between cholecystectomy and colorectal cancer in the Icelandic population was analyzed in a historical prospective study. A total of 3,425 individuals (857 males and 2,568 females) who underwent cholecystectomy during a 26-yr period (1955-1980) were followed for 8-33 yr. The risk of colonic cancer in Icelandic males increased significantly 11 yr or more after operation (relative risk, 2.73; 95% confidence interval, 1.25-5.19). This is the only study that shows a significantly increased risk of colonic cancer in males only. In spite of this increased risk, regular screening for colonic cancer in Icelandic males would probably not be warranted, since almost 70% of the males are 70 yr old or older at the time of diagnosis.
在一项历史性前瞻性研究中，分析了冰岛人群中胆囊切除术与结直肠癌之间的关系。在26年期间（1955年至1980年）接受胆囊切除术的3425人（857名男性和2568名女性）被随访了8至33年。冰岛男性在手术后11年或更长时间患结肠癌的风险显著增加（相对风险，2.73；95%置信区间，1.25至5.19）。这是唯一一项显示仅男性患结肠癌风险显著增加的研究。尽管有这种增加的风险，但冰岛男性可能没有必要进行常规的结肠癌筛查，因为几乎70%的男性在诊断时已年满70岁或以上。
