Caprilli R, Ciarniello P, De Petris G, Giuliano M, Saltarelli P, Spagnolo A
Cattedra di Gastroenterologia, Università di L'Aquila.
Ital J Surg Sci. 1989;19(1):29-35.
A case-double control study on 318 personally interviewed patients with large bowel neoplasia has been carried out to establish the possible role of cholecystectomy in the development of colorectal cancer. The dietary habits both of the cancer patients and control subjects were investigated. All controls were considered free of neoplastic lesions on the basis of a negative fecal occult blood test. Data from the study showed that the prevalence of cholecystectomy in the overall patients was similar to that of the two control groups. However, analysing the data for colon and rectum, the relative risk of colonic cancer after cholecystectomy was significantly increased in males (RR = 2.75; p less than 0.05), whereas that of rectal cancer appeared to be decreased in females (RR = 0.18; p less than 0.02). Subsite analysis demonstrated that right-sided neoplasia after long-standing cholecystectomy (greater than or equal to 10 years) was responsible for the increased colonic risk. In conclusion, the present data support the hypothesis that cholecystectomy may be considered a risk factor for right-sided colon cancer, but indicate that this operation seems to play a protective role for rectal cancer.
一项针对318名接受个人访谈的大肠肿瘤患者开展的病例-双对照研究，旨在确定胆囊切除术在结直肠癌发生过程中可能起到的作用。对癌症患者和对照受试者的饮食习惯均进行了调查。所有对照基于粪便潜血试验呈阴性，被认为无肿瘤性病变。研究数据显示，总体患者中胆囊切除术的患病率与两个对照组相似。然而，分析结肠和直肠的数据时，胆囊切除术后男性患结肠癌的相对风险显著增加（RR = 2.75；p < 0.05），而女性患直肠癌的相对风险似乎降低（RR = 0.18；p < 0.02）。亚部位分析表明，长期（大于或等于10年）胆囊切除术后右侧肿瘤是结肠风险增加的原因。总之，目前的数据支持以下假设：胆囊切除术可能被视为右侧结肠癌的一个风险因素，但表明该手术似乎对直肠癌起到保护作用。
