Sonne Charlotte, Carlsson Jessica, Bech Per, Vindbjerg Erik, Mortensen Erik Lykke, Elklit Ask
Competence Centre for Transcultural Psychiatry, Mental Health Centre Ballerup, University of Southern Denmark, Ballerup, Denmark;
Competence Centre for Transcultural Psychiatry, University of Copenhagen, Copenhagen, Denmark.
Eur J Psychotraumatol. 2016 May 31;7:30907. doi: 10.3402/ejpt.v7.30907. eCollection 2016.
The effects of treatment in trials with trauma-affected refugees vary considerably not only between studies but also between patients within a single study. However, we know little about why some patients benefit more from treatment, as few studies have analysed predictors of treatment outcome.
The objective of the study was to examine possible psychosocial predictors of treatment outcome for trauma-affected refugees.
The participants were 195 adult refugees with posttraumatic stress disorder (PTSD) who were enrolled in a 6- to 7-month treatment programme at the Competence Centre for Transcultural Psychiatry (CTP), Denmark. The CTP Predictor Index used in the study included 15 different possible outcome predictors concerning the patients' past, chronicity of mental health problems, pain, treatment motivation, prerequisites for engaging in psychotherapy, and social situation. The primary outcome measure was PTSD symptoms measured on the Harvard Trauma Questionnaire (HTQ). Other outcome measures included the Hopkins Symptom Check List-25, the WHO-5 Well-being Index, Sheehan Disability Scale, Hamilton Depression and Anxiety Scales, the somatisation scale of the Symptoms Checklist-90, Global Assessment of Functioning scales, and pain rated on visual analogue scales. The relations between treatment outcomes and the total score as well as subscores of the CTP Predictor Index were analysed.
Overall, the total score of the CTP Predictor Index was significantly correlated to pre- to post treatment score changes on the majority of the ratings mentioned above. While employment status was the only single item significantly correlated to HTQ-score changes, a number of single items from the CTP Predictor Index correlated significantly with changes in depression and anxiety symptoms, but the size of the correlation coefficients were modest.
The total score of the CTP Predictor Index correlated significantly with outcomes on most of the rating scales, but correlations were modest in size, possibly due to the number of different factors influencing treatment outcome.
在创伤影响难民的试验中,治疗效果差异很大,不仅在不同研究之间,而且在单个研究中的患者之间也是如此。然而,我们对为何有些患者从治疗中获益更多知之甚少,因为很少有研究分析治疗结果的预测因素。
本研究的目的是检查创伤影响难民治疗结果的可能心理社会预测因素。
参与者为195名患有创伤后应激障碍(PTSD)的成年难民,他们参加了丹麦跨文化精神病学能力中心(CTP)为期6至7个月的治疗项目。该研究中使用的CTP预测指数包括15个不同的可能结果预测因素,涉及患者的过去、心理健康问题的慢性程度、疼痛、治疗动机、参与心理治疗的前提条件以及社会状况。主要结局指标是用哈佛创伤问卷(HTQ)测量的PTSD症状。其他结局指标包括霍普金斯症状清单-25、世界卫生组织-5幸福指数、希恩残疾量表、汉密尔顿抑郁和焦虑量表、症状清单-90的躯体化量表、功能总体评估量表以及视觉模拟量表评定的疼痛。分析了治疗结果与CTP预测指数总分及子分数之间的关系。
总体而言,CTP预测指数总分与上述大多数评定指标治疗前至治疗后的分数变化显著相关。虽然就业状况是唯一与HTQ分数变化显著相关的单个项目,但CTP预测指数中的一些单个项目与抑郁和焦虑症状的变化显著相关,但相关系数大小适中。
CTP预测指数总分与大多数评定量表的结果显著相关,但相关系数大小适中,可能是由于影响治疗结果的不同因素数量所致。