癌症的特征与富含AU元件

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1368. Epub 2016 Jun 1.

Post-transcriptional control of gene expression is aberrant in cancer cells. Sustained stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU-rich elements (AREs), cis-acting mRNA decay determinants, play a major role in the posttranscriptional regulation of many genes involved in cancer processes. This review discusses the role of aberrant ARE-mediated posttranscriptional processes in each of the hallmarks of cancer, including sustained cellular growth, resistance to apoptosis, angiogenesis, invasion, and metastasis. WIREs RNA 2017, 8:e1368. doi: 10.1002/wrna.1368 For further resources related to this article, please visit the WIREs website.

基因表达的转录后调控在癌细胞中是异常的。特定mRNA的持续稳定和翻译增强是肿瘤细胞的特征。富含AU元件（AREs），即顺式作用的mRNA衰变决定因素，在许多参与癌症进程的基因的转录后调控中起主要作用。本综述讨论了异常的ARE介导的转录后过程在癌症的每个标志中的作用，包括持续的细胞生长、抗凋亡、血管生成、侵袭和转移。WIREs RNA 2017年，8:e1368。doi:10.1002/wrna.1368 有关本文的更多资源，请访问WIREs网站。

相似文献

Hallmarks of cancer and AU-rich elements.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1368. Epub 2016 Jun 1.

Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of AU-rich elements and associated proteins.

J Interferon Cytokine Res. 2014 Apr;34(4):242-54. doi: 10.1089/jir.2013.0140.

Dysregulation of TTP and HuR plays an important role in cancers.

Tumour Biol. 2016 Nov;37(11):14451-14461. doi: 10.1007/s13277-016-5397-z. Epub 2016 Sep 19.

Regulatory effects of cotranscriptional RNA structure formation and transitions.

Wiley Interdiscip Rev RNA. 2016 Sep;7(5):562-74. doi: 10.1002/wrna.1350. Epub 2016 Mar 29.

Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA.

Cancer Res. 1997 Dec 1;57(23):5426-33.

mRNA methylation by NSUN2 in cell proliferation.

Wiley Interdiscip Rev RNA. 2016 Nov;7(6):838-842. doi: 10.1002/wrna.1380. Epub 2016 Jul 22.

The role of mRNA structure in bacterial translational regulation.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1370. Epub 2016 Jun 14.

Ribosome-based quality control of mRNA and nascent peptides.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1366. Epub 2016 May 18.

Emerging roles of hnRNPA1 in modulating malignant transformation.

Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1431. Epub 2017 Aug 8.

Activation of p38 signaling increases utrophin A expression in skeletal muscle via the RNA-binding protein KSRP and inhibition of AU-rich element-mediated mRNA decay: implications for novel DMD therapeutics.

Hum Mol Genet. 2013 Aug 1;22(15):3093-111. doi: 10.1093/hmg/ddt165. Epub 2013 Apr 10.

引用本文的文献

Unstructured protein domains stabilize RNA binding and mediate RNA folding by AUF1.

J Biol Chem. 2025 May;301(5):108442. doi: 10.1016/j.jbc.2025.108442. Epub 2025 Mar 25.

HuR (ELAVL1) Stabilizes mRNA and Promotes Migration and Invasion in Breast Cancer Cells.

Cancers (Basel). 2024 Jan 16;16(2):384. doi: 10.3390/cancers16020384.

Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop.

Oncogene. 2024 Jan;43(1):47-60. doi: 10.1038/s41388-023-02880-7. Epub 2023 Nov 7.

The 3'‑untranslated region of XB130 regulates its mRNA stability and translational efficiency in non‑small cell lung cancer cells.

Oncol Lett. 2023 Aug 17;26(4):427. doi: 10.3892/ol.2023.14013. eCollection 2023 Oct.

Surmounting Cancer Drug Resistance: New Perspective on RNA-Binding Proteins.

Pharmaceuticals (Basel). 2023 Aug 7;16(8):1114. doi: 10.3390/ph16081114.

The RNA-binding protein KSRP aggravates malignant progression of clear cell renal cell carcinoma through transcriptional inhibition and post-transcriptional destabilization of the NEDD4L ubiquitin ligase.

J Biomed Sci. 2023 Aug 14;30(1):68. doi: 10.1186/s12929-023-00949-9.

New Functions of Intracellular LOXL2: Modulation of RNA-Binding Proteins.

Molecules. 2023 May 30;28(11):4433. doi: 10.3390/molecules28114433.

FOXO1 Is a Key Mediator of Glucocorticoid-Induced Expression of Tristetraprolin in MDA-MB-231 Breast Cancer Cells.

Int J Mol Sci. 2022 Nov 8;23(22):13673. doi: 10.3390/ijms232213673.

Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.

Nucleic Acids Res. 2022 Oct 14;50(18):10665-10679. doi: 10.1093/nar/gkac797.

Analysis of ROQUIN, Tristetraprolin (TTP), and BDNF/miR-16/TTP regulatory axis in late onset Alzheimer's disease.

Front Aging Neurosci. 2022 Aug 9;14:933019. doi: 10.3389/fnagi.2022.933019. eCollection 2022.

本文引用的文献

Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins.

Cancer Res. 2016 Jul 15;76(14):4068-80. doi: 10.1158/0008-5472.CAN-15-3110. Epub 2016 May 17.

Tristetraprolin inhibits gastric cancer progression through suppression of IL-33.

Sci Rep. 2016 Apr 14;6:24505. doi: 10.1038/srep24505.

Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer.

Sci Rep. 2016 Mar 1;6:22449. doi: 10.1038/srep22449.

Tristetraprolin suppresses the EMT through the down-regulation of Twist1 and Snail1 in cancer cells.

Oncotarget. 2016 Feb 23;7(8):8931-43. doi: 10.18632/oncotarget.7094.

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1865-70. doi: 10.1073/pnas.1519906113. Epub 2016 Feb 1.

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.

RNA. 2016 Mar;22(3):373-82. doi: 10.1261/rna.054833.115. Epub 2016 Jan 13.

Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15916-21. doi: 10.1073/pnas.1513034112. Epub 2015 Dec 14.

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function.

Sci Rep. 2015 Nov 10;5:16478. doi: 10.1038/srep16478.

Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance.

J Biol Chem. 2016 Jan 1;291(1):291-302. doi: 10.1074/jbc.M115.693853. Epub 2015 Nov 2.

Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway.

Oncotarget. 2015 Dec 8;6(39):41679-91. doi: 10.18632/oncotarget.6149.

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1368. Epub 2016 Jun 1.

相似文献

Hallmarks of cancer and AU-rich elements.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1368. Epub 2016 Jun 1.

Control of pro-angiogenic cytokine mRNA half-life in cancer: the role of AU-rich elements and associated proteins.

J Interferon Cytokine Res. 2014 Apr;34(4):242-54. doi: 10.1089/jir.2013.0140.

Dysregulation of TTP and HuR plays an important role in cancers.

Tumour Biol. 2016 Nov;37(11):14451-14461. doi: 10.1007/s13277-016-5397-z. Epub 2016 Sep 19.

Regulatory effects of cotranscriptional RNA structure formation and transitions.

Wiley Interdiscip Rev RNA. 2016 Sep;7(5):562-74. doi: 10.1002/wrna.1350. Epub 2016 Mar 29.

Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA.

Cancer Res. 1997 Dec 1;57(23):5426-33.

mRNA methylation by NSUN2 in cell proliferation.

Wiley Interdiscip Rev RNA. 2016 Nov;7(6):838-842. doi: 10.1002/wrna.1380. Epub 2016 Jul 22.

The role of mRNA structure in bacterial translational regulation.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1370. Epub 2016 Jun 14.

Ribosome-based quality control of mRNA and nascent peptides.

Wiley Interdiscip Rev RNA. 2017 Jan;8(1). doi: 10.1002/wrna.1366. Epub 2016 May 18.

Emerging roles of hnRNPA1 in modulating malignant transformation.

Wiley Interdiscip Rev RNA. 2017 Nov;8(6). doi: 10.1002/wrna.1431. Epub 2017 Aug 8.

Hum Mol Genet. 2013 Aug 1;22(15):3093-111. doi: 10.1093/hmg/ddt165. Epub 2013 Apr 10.

引用本文的文献

Unstructured protein domains stabilize RNA binding and mediate RNA folding by AUF1.

J Biol Chem. 2025 May;301(5):108442. doi: 10.1016/j.jbc.2025.108442. Epub 2025 Mar 25.

HuR (ELAVL1) Stabilizes mRNA and Promotes Migration and Invasion in Breast Cancer Cells.

Cancers (Basel). 2024 Jan 16;16(2):384. doi: 10.3390/cancers16020384.

Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop.

Oncogene. 2024 Jan;43(1):47-60. doi: 10.1038/s41388-023-02880-7. Epub 2023 Nov 7.

The 3'‑untranslated region of XB130 regulates its mRNA stability and translational efficiency in non‑small cell lung cancer cells.

Oncol Lett. 2023 Aug 17;26(4):427. doi: 10.3892/ol.2023.14013. eCollection 2023 Oct.

Surmounting Cancer Drug Resistance: New Perspective on RNA-Binding Proteins.

Pharmaceuticals (Basel). 2023 Aug 7;16(8):1114. doi: 10.3390/ph16081114.

J Biomed Sci. 2023 Aug 14;30(1):68. doi: 10.1186/s12929-023-00949-9.

New Functions of Intracellular LOXL2: Modulation of RNA-Binding Proteins.

Molecules. 2023 May 30;28(11):4433. doi: 10.3390/molecules28114433.

FOXO1 Is a Key Mediator of Glucocorticoid-Induced Expression of Tristetraprolin in MDA-MB-231 Breast Cancer Cells.

Int J Mol Sci. 2022 Nov 8;23(22):13673. doi: 10.3390/ijms232213673.

Intrinsically disordered regions of tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA.

Nucleic Acids Res. 2022 Oct 14;50(18):10665-10679. doi: 10.1093/nar/gkac797.

Analysis of ROQUIN, Tristetraprolin (TTP), and BDNF/miR-16/TTP regulatory axis in late onset Alzheimer's disease.

Front Aging Neurosci. 2022 Aug 9;14:933019. doi: 10.3389/fnagi.2022.933019. eCollection 2022.

本文引用的文献

Systematic Analysis of AU-Rich Element Expression in Cancer Reveals Common Functional Clusters Regulated by Key RNA-Binding Proteins.

Cancer Res. 2016 Jul 15;76(14):4068-80. doi: 10.1158/0008-5472.CAN-15-3110. Epub 2016 May 17.

Tristetraprolin inhibits gastric cancer progression through suppression of IL-33.

Sci Rep. 2016 Apr 14;6:24505. doi: 10.1038/srep24505.

Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer.

Sci Rep. 2016 Mar 1;6:22449. doi: 10.1038/srep22449.

Tristetraprolin suppresses the EMT through the down-regulation of Twist1 and Snail1 in cancer cells.

Oncotarget. 2016 Feb 23;7(8):8931-43. doi: 10.18632/oncotarget.7094.

Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1865-70. doi: 10.1073/pnas.1519906113. Epub 2016 Feb 1.

Recruitment of the 4EHP-GYF2 cap-binding complex to tetraproline motifs of tristetraprolin promotes repression and degradation of mRNAs with AU-rich elements.

RNA. 2016 Mar;22(3):373-82. doi: 10.1261/rna.054833.115. Epub 2016 Jan 13.

Human RNase L tunes gene expression by selectively destabilizing the microRNA-regulated transcriptome.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15916-21. doi: 10.1073/pnas.1513034112. Epub 2015 Dec 14.

Dihydrotanshinone-I interferes with the RNA-binding activity of HuR affecting its post-transcriptional function.

Sci Rep. 2015 Nov 10;5:16478. doi: 10.1038/srep16478.

Loss of Scribble Promotes Snail Translation through Translocation of HuR and Enhances Cancer Drug Resistance.

J Biol Chem. 2016 Jan 1;291(1):291-302. doi: 10.1074/jbc.M115.693853. Epub 2015 Nov 2.

Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway.

Oncotarget. 2015 Dec 8;6(39):41679-91. doi: 10.18632/oncotarget.6149.

Hallmarks of cancer and AU-rich elements.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献

文献AI研究员

用中文搜PubMed

文档翻译

Suppr 超能文献

癌症的特征与富含AU元件

Hallmarks of cancer and AU-rich elements.

作者信息

机构信息

出版信息

相似文献

引用本文的文献

本文引用的文献