Shirai Mai, Yamamoto Ryuji, Chiba Toshie, Komatsu Koichiro, Shimoda Shinji, Yamakoshi Yasuo, Oida Shinichiro, Ohkubo Chikahiro
Department of Removable Prosthodontics, Tsurumi University School of Dental Medicine.
Dent Mater J. 2016;35(3):470-8. doi: 10.4012/dmj.2016-026.
This study was designed to evaluate the volume of alveolar bone augmentation after immediate implant placement using demineralized bone. We examined the collagen matrix of demineralized bone and biologically active substances contained therein. Rat maxillary first molars were extracted, and the animals were divided into five groups as follows: tooth extraction only, implant into the mesial root socket, implant and other root sockets covered with demineralized bone sheet, implant and other root sockets filled with demineralized bone powder under the sheet, and implant and other root sockets covered with demineralized bone sheet from which proteins were extracted. We ascertained whether biologically active substances are contained in extracted proteins. Biologically active substances were detected in extracted proteins. Conditions using demineralized bone sheet with biologically active substances significantly augmented the height of the alveolar bone. Such resorbable membranes containing biologically active substances hold promise as clinical agents for bone augmentation upon implantation.
本研究旨在评估使用脱矿骨即刻种植后牙槽骨增量的体积。我们检查了脱矿骨的胶原基质及其所含的生物活性物质。拔除大鼠上颌第一磨牙，并将动物分为以下五组：仅拔牙组、种植于近中牙根窝组、种植且其他牙根窝覆盖脱矿骨片组、种植且其他牙根窝在骨片下填充脱矿骨粉组、种植且其他牙根窝覆盖已提取蛋白质的脱矿骨片组。我们确定提取的蛋白质中是否含有生物活性物质。在提取的蛋白质中检测到了生物活性物质。使用含有生物活性物质的脱矿骨片的情况显著增加了牙槽骨的高度。这种含有生物活性物质的可吸收膜有望作为植入时骨增量的临床制剂。
