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评论：糖尿病中的线粒体DNA损伤与缺失

Commentary: Mitochondrial DNA damage and loss in diabetes.

作者信息

Gilkerson Robert

机构信息

Departments of Biology, The University of Texas Rio Grande Valley, Edinburg, TX, USA.

Clinical Laboratory Sciences, The University of Texas Rio Grande Valley, Edinburg, TX, USA.

出版信息

Diabetes Metab Res Rev. 2016 Oct;32(7):672-674. doi: 10.1002/dmrr.2833. Epub 2016 Jun 30.

DOI:10.1002/dmrr.2833
PMID:27253402
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5248653/
Abstract

This commentary discusses damage and loss of mitochondrial DNA (mtDNA) in type 2 diabetes mellitus from both the clinical and experimental perspectives. Increasingly, an array of studies in experimental models and patients suggests that the cellular stresses of insulin resistance in type 2 diabetes damage mtDNA, leading to loss of mitochondrial genetic content. As such, mtDNA is emerging as both a valuable monitoring tool and translational preventive target for metabolic disease. Copyright © 2016 John Wiley & Sons, Ltd.

摘要

本评论从临床和实验角度探讨了2型糖尿病中线粒体DNA（mtDNA）的损伤和丢失。越来越多针对实验模型和患者的研究表明，2型糖尿病中胰岛素抵抗所产生的细胞应激会损伤mtDNA，导致线粒体遗传物质丢失。因此，mtDNA正逐渐成为代谢性疾病的一种有价值的监测工具和转化性预防靶点。版权所有© 2016约翰·威利父子有限公司。

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本文引用的文献

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Metabolism. 2015 Sep;64(9):999-1004. doi: 10.1016/j.metabol.2015.06.008. Epub 2015 Jun 16.
2
Mitochondrial transcription factor A regulation of mitochondrial degeneration in experimental diabetic neuropathy.线粒体转录因子A对实验性糖尿病性神经病变中线粒体变性的调控
Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E132-41. doi: 10.1152/ajpendo.00620.2014. Epub 2015 May 5.
3
High-fat, low-carbohydrate diet alters myocardial oxidative stress and impairs recovery of cardiac function after ischemia and reperfusion in obese rats.高脂肪、低碳水化合物饮食改变肥胖大鼠心肌氧化应激，损害缺血再灌注后心功能的恢复。
Nutr Res. 2013 Apr;33(4):311-21. doi: 10.1016/j.nutres.2013.02.005. Epub 2013 Mar 26.
4
"Deficiency" of mitochondria in muscle does not cause insulin resistance.肌肉中线粒体的“缺乏”并不会导致胰岛素抵抗。
Diabetes. 2013 Apr;62(4):1036-40. doi: 10.2337/db12-1107.
5
Mitochondrial DNA maintenance is regulated in human hepatoma cells by glycogen synthase kinase 3β and p53 in response to tumor necrosis factor α.人肝癌细胞中糖原合酶激酶 3β和 p53 通过响应肿瘤坏死因子 α 来调节线粒体 DNA 的维持。
PLoS One. 2012;7(7):e40879. doi: 10.1371/journal.pone.0040879. Epub 2012 Jul 20.
6
Correlative 3D superresolution fluorescence and electron microscopy reveal the relationship of mitochondrial nucleoids to membranes.相关的 3D 超分辨率荧光和电子显微镜揭示了线粒体类核与膜的关系。
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6136-41. doi: 10.1073/pnas.1121558109. Epub 2012 Apr 2.
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Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance.炎症对于长期而非短期高脂肪饮食诱导的胰岛素抵抗是必要的。
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