Mráz Miloš, Svačina Štěpán, Kotrlíková Eva, Piecha Roman, Vrbík Karel, Pavloušková Jana, Lacinová Zdeňka, Vavrouš Adam, Müllerová Dana, Matějková Dagmar, Křížová Jarmila
Cas Lek Cesk. 2016;155(3):11-5.
Nowadays, there is increasing evidence showing that the development of the metabolic syndrome combining obesity, type 2 diabetes mellitus, arterial hypertension and dyslipidemia involves except of traditional risk factors (overnutrition, lack of physical activity, genetic predisposition) also the effect of environmental organic substances called organic pollutants or endocrine disruptors. These chemicals can be found in plastic covers, paints, flame retardants, exhaust gases, fertilizers as well as diverse daily utensils. Phthalates, used primarily as plasticizers, and bisphenol A, are among the most wide-spread members of this group.The aim of this article is to provide a basic overview of the relationship between phthalates and bisphenol A and the etiopathogenesis of the metabolic syndrome and to highlight their potential sources. According to the analysis of materials used for parenteral nutrition and urinary excretion of phthalate metabolites and bisphenol A in subjects on long-term parenteral nutrition we suppose that currently used medical materials are safe with respect to the exposure to both phthalates and bisphenol A and that home environment, especially cosmetic products, might constitute a more probable source of these substances.
如今，越来越多的证据表明，代谢综合征（合并肥胖、2型糖尿病、动脉高血压和血脂异常）的发展除了涉及传统危险因素（营养过剩、缺乏体育活动、遗传易感性）外，还涉及被称为有机污染物或内分泌干扰物的环境有机物质的影响。这些化学物质存在于塑料包装、涂料、阻燃剂、废气、肥料以及各种日常用具中。邻苯二甲酸盐主要用作增塑剂，双酚A是该类物质中分布最广的成员。本文旨在对邻苯二甲酸盐和双酚A与代谢综合征的病因之间的关系进行基本概述，并突出它们的潜在来源。根据对长期接受肠外营养的受试者使用的肠外营养材料以及邻苯二甲酸酯代谢物和双酚A的尿排泄情况的分析，我们认为目前使用的医疗材料在接触邻苯二甲酸盐和双酚A方面是安全的，家庭环境，尤其是化妆品，可能是这些物质更可能的来源。
