Department of Medicine, Columbia University Medical Center, MH 6C-12, New York, NY, 10032, USA.
Department of Pediatrics, Columbia University Medical Center, New York, NY, USA.
Curr Environ Health Rep. 2015 Dec;2(4):379-87. doi: 10.1007/s40572-015-0066-8.
In recent years, the impact of environmental exposure to chemicals and their immunological effects, including the development of allergy, has been a topic of great interest. Epidemiologic studies indicate that exposure to endocrine-disrupting chemicals produced in high volumes, including bisphenol A (BPA) and phthalates, is ubiquitous. The links between their exposure and the development of allergy, asthma, and immune dysfunction have been studied in vitro, in vivo, and through human cohort studies. The purpose of this review is to examine the current body of research and to highlight deficits and strengths of current findings. Emerging science indicates that deleterious immunologic changes, including increased propensity to develop wheeze, allergy, and asthma after dietary and inhalation exposure to these chemicals, may be occurring.
近年来，环境中化学物质暴露及其免疫学效应（包括过敏的发生）的影响一直是人们关注的热点。流行病学研究表明，广泛存在着暴露于大量产生的内分泌干扰化学物质，包括双酚 A（BPA）和邻苯二甲酸酯。其暴露与过敏、哮喘和免疫功能障碍的发展之间的联系已在体外、体内以及通过人类队列研究进行了研究。本综述的目的是检查当前的研究现状，并突出当前研究结果的不足和优势。新兴科学表明，这些化学物质经饮食和吸入暴露后，可能会导致有害的免疫变化，包括发生喘息、过敏和哮喘的倾向增加。
