一种在水中具有高选择性和高灵敏度的基于光致电子转移（PET）的次氯酸荧光探针及其在活细胞中的内源性成像。
A highly selective and sensitive photoinduced electron transfer (PET) based HOCl fluorescent probe in water and its endogenous imaging in living cells.
作者信息
Liang Lijuan, Liu Chang, Jiao Xiaojie, Zhao Liancheng, Zeng Xianshun
机构信息
School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.
出版信息
Chem Commun (Camb). 2016 Jun 28;52(51):7982-5. doi: 10.1039/c6cc02603f. Epub 2016 Jun 3.
A probe based on the phenothiazine-acridine orange conjugate (Ptz-AO) has been designed and synthesized for the sensitive and selective detection of HOCl. Ptz-AO has excellent properties, including pH-independence of fluorescence, high resistance to photobleaching, and response in real time. The value of Ptz-AO was confirmed by exogenous, endogenous and the real-time imaging of HOCl in vitro using a fluorescence microscope.
一种基于吩噻嗪-吖啶橙共轭物（Ptz-AO）的探针已被设计并合成出来，用于对次氯酸（HOCl）进行灵敏且选择性的检测。Ptz-AO具有优异的性能，包括荧光不依赖于pH、对光漂白具有高抗性以及实时响应。通过外源、内源以及使用荧光显微镜在体外对HOCl进行实时成像，证实了Ptz-AO的价值。
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