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一种用于对活细胞中次氯酸氧化和半胱氨酸/同型半胱氨酸还原过程进行成像的新型荧光探针。

A novel fluorescent probe for imaging the process of HOCl oxidation and Cys/Hcy reduction in living cells.

作者信息

Liu Zhen, Li Guoping, Wang Yana, Li Jiulong, Mi Yang, Guo Linna, Xu Wenjian, Zou Dapeng, Li Tiesheng, Wu Yangjie

机构信息

The College of Chemistry and Molecular Engineering, Zhengzhou University Zhengzhou 450001 Henan Province P. R. China

School of Basic Medical Sciences, Zhengzhou University Zhengzhou 450001 Henan Province P. R. China.

出版信息

RSC Adv. 2018 Mar 5;8(17):9519-9523. doi: 10.1039/c7ra13419c. eCollection 2018 Feb 28.

DOI:10.1039/c7ra13419c
PMID:35541868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9078674/
Abstract

A new on-off-on fluorescent probe, CMOS, based on coumarin was developed to detect the process of hypochlorous acid (HOCl) oxidative stress and cysteine/homocysteine (Cys/Hcy) reduction. The probe exhibited a fast response, good sensitivity and selectivity. Moreover, it was applied for monitoring the redox process in living cells.

摘要

一种基于香豆素的新型开关型荧光探针CMOS被开发出来，用于检测次氯酸（HOCl）氧化应激和半胱氨酸/同型半胱氨酸（Cys/Hcy）还原过程。该探针具有快速响应、良好的灵敏度和选择性。此外，它还被应用于监测活细胞中的氧化还原过程。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/b2cce709e0a9/c7ra13419c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/9f7f6dcfdd69/c7ra13419c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/51a982ab3113/c7ra13419c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/541933e09595/c7ra13419c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/fc8004fe1663/c7ra13419c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/78c8367c64c0/c7ra13419c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/b2cce709e0a9/c7ra13419c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/9f7f6dcfdd69/c7ra13419c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/51a982ab3113/c7ra13419c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/541933e09595/c7ra13419c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/fc8004fe1663/c7ra13419c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/78c8367c64c0/c7ra13419c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48a4/9078674/b2cce709e0a9/c7ra13419c-f5.jpg

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