Judge Chelsey J, Sandberg Johan K, Funderburg Nicholas T, Sherman Kenneth E, Butt Adeel A, Kang Minhee, Landay Alan L, Lederman Michael M, Anthony Donald D
*Department of Pathology, The Cleveland VA Medical Center, Case Western Reserve University, Cleveland, OH; †Center for Infection Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden; ‡School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, The Ohio State University, Columbus, OH; §University of Cincinnati Medical Center, Cincinnati, OH; ‖Weill Cornell Medical College, New York, NY; ¶Hamd Healthcare Quality Institute and Hamad Medical Corporation, Doha, Qatar; #Harvard T.H. Chan School of Public Health, Boston, MA, USA **Rush University Medical Center, Chicago, IL; and ††Department of Medicine, University Hospitals Case Medical Center, and the Center for AIDS Research, Cleveland, OH.
J Acquir Immune Defic Syndr. 2016 Nov 1;73(3):258-262. doi: 10.1097/QAI.0000000000001104.
During HIV+ hepatitis C virus (HCV)+ coinfection CD14CD16 monocytes produce soluble immune-activation markers that predict disease progression and poor response to interferon (IFN)-α treatment. We evaluated relationships among immune activation, monocyte phenotype, CD4-memory T cells, and HCV-, cytomegalovirus-, and cytomegalovirus/Epstein-Barr virus/influenza-specific IFN-γ-response before and during IFN-α treatment. Effector-memory and central-memory CD4 T-cell frequencies were lower in HCV+ HIV+ donors than in uninfected donors and correlated negatively with HCV level, CD14CD16 monocytes, and plasma sCD14. sCD14 and CD14CD16 monocytes negatively correlated with IFN-α-dependent HCV decline. CD4 effector-memory T cells positively associated with cytomegalovirus/Epstein-Barr virus/influenza(CEF)-specific IFN-γ response, while sCD14 negatively associated with both CD4 effector-memory T cells and CEF-specific IFN-γ response. These data support a role for memory-CD4 T cells in HCV containment and link immune activation and CD14CD16-monocyte frequency to the failure of IFN-dependent HCV clearance.
在HIV与丙型肝炎病毒（HCV）合并感染期间，CD14CD16单核细胞会产生可预测疾病进展以及对干扰素（IFN）-α治疗反应不佳的可溶性免疫激活标志物。我们评估了IFN-α治疗之前及期间免疫激活、单核细胞表型、CD4记忆T细胞以及HCV特异性、巨细胞病毒特异性、巨细胞病毒/爱泼斯坦-巴尔病毒/流感特异性IFN-γ反应之间的关系。与未感染的供体相比，HCV阳性HIV阳性供体中的效应记忆和中枢记忆CD4 T细胞频率更低，且与HCV水平、CD14CD16单核细胞以及血浆sCD14呈负相关。sCD14和CD14CD16单核细胞与IFN-α依赖的HCV下降呈负相关。CD4效应记忆T细胞与巨细胞病毒/爱泼斯坦-巴尔病毒/流感（CEF）特异性IFN-γ反应呈正相关，而sCD14与CD4效应记忆T细胞以及CEF特异性IFN-γ反应均呈负相关。这些数据支持记忆性CD4 T细胞在控制HCV方面的作用，并将免疫激活和CD14CD16单核细胞频率与IFN依赖的HCV清除失败联系起来。
