Cairncross Carolyn, Grant Cameron, Stonehouse Welma, Conlon Cath, McDonald Barry, Houghton Lisa, Eyles Darryl, Camargo Carlos A, Coad Jane, von Hurst Pamela
School of Food and Nutrition, Massey University, Auckland 0632, New Zealand.
Department of Paediatrics, University of Auckland and General Paediatrics, Auckland 1010, New Zealand.
Nutrients. 2016 Jun 1;8(6):326. doi: 10.3390/nu8060326.
Recent research on vitamin D in young children has expanded from bone development to exploring immunomodulatory effects. Our aim was to investigate the relationship of vitamin D status and allergic diseases in preschool-aged children in New Zealand. Dried capillary blood spots were collected from 1329 children during late-winter to early-spring for 25(OH)D measurement by LC-MS/MS. Caregivers completed a questionnaire about their child's recent medical history. Analysis was by multivariable logistic regression. Mean 25(OH)D concentration was 52(SD19) nmol/L, with 7% of children <25 nmol/L and 49% <50 nmol/L. Children with 25(OH)D concentrations ≥75 nmol/L (n = 29) had a two-fold increased risk for parent-report of doctor-diagnosed food allergy compared to children with 25(OH)D 50-74.9 nmol/L (OR = 2.21, 1.33-3.68, p = 0.002). No associations were present between 25(OH)D concentration and presence of parent-reported eczema, allergic rhinoconjunctivitis or atopic asthma. Vitamin D deficiency was not associated with several allergic diseases in these New Zealand preschool children. In contrast, high 25(OH)D concentrations were associated with a two-fold increased risk of parental-report food allergy. This increase supports further research into the association between vitamin D status and allergic disease in preschool children.
近期关于幼儿维生素D的研究已从骨骼发育扩展到探索免疫调节作用。我们的目的是调查新西兰学龄前儿童维生素D状况与过敏性疾病之间的关系。在冬末至早春期间收集了1329名儿童的干毛细血管血斑，通过液相色谱-串联质谱法测定25(OH)D。照顾者完成了一份关于其孩子近期病史的问卷。采用多变量逻辑回归进行分析。25(OH)D平均浓度为52（标准差19）nmol/L，7%的儿童<25 nmol/L，49%的儿童<50 nmol/L。与25(OH)D浓度在50 - 74.9 nmol/L的儿童相比，25(OH)D浓度≥75 nmol/L（n = 29）的儿童经家长报告医生诊断的食物过敏风险增加了两倍（比值比=2.21，1.33 - 3.68，p = 0.002）。25(OH)D浓度与家长报告的湿疹、过敏性鼻结膜炎或特应性哮喘之间无关联。在这些新西兰学龄前儿童中，维生素D缺乏与几种过敏性疾病无关。相反，高25(OH)D浓度与家长报告的食物过敏风险增加两倍有关联。这一增加支持了对学龄前儿童维生素D状况与过敏性疾病之间关联的进一步研究。
