Barlianto Wisnu, Wulandari Desy, Sari Tita Luthfia, Firdayanti Vanisia Hayu, Avandi Muhammad Irvan
Division of Allergy and Immunology, Paediatric Department, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia.
Pediatric Department, Faculty of Medicine, Brawijaya University, Malang, East Java, Indonesia.
Postepy Dermatol Alergol. 2022 Aug;39(4):793-799. doi: 10.5114/ada.2022.118923. Epub 2022 Sep 1.
Atopic dermatitis (AD) is an immune-mediated inflammatory skin disease and generally develops in infancy. Studies evaluating the role of vitamin D in immune mechanims in AD showed varying results.
To assess the association between serum vitamin D, cytokine profiles, and disease severity in infants with AD.
A cross-sectional study was conducted on infants aged 0-12 months with AD in the Paediatric Allergy and Immunology Department, Saiful Anwar Hospital, Indonesia. The disease severity was assessed by the Scoring of Atopic Dermatitis (SCORAD) index. Blood was drawn to evaluate the total eosinophil count (TEC), total immunoglobulin E (tIgE), 25-hydroxyvitamin D (25(OH)D), interleukin-4 (IL-4), IL-17A, and IL-22 levels.
This study enrolled 36 infants including 19 with mild AD and 17 with moderate AD. Vitamin D deficiency and insufficiency were found in 18 (50%) and 9 (25%) subjects, respectively. The mean 25(OH)D level was lower and the mean IL-4, IL-17A, and IL-22 levels were higher in the moderate AD group than in the mild AD group ( < 0.05). A lower level of 25(OH)D was associated with a higher level of IL-17A ( = -0.315, = 0.041). The SCORAD index was negatively correlated with 25(OH)D ( = -0.714, < 0.001) and positively correlated with IL-17A ( = 0.522, = 0.001) and IL-22 ( = 0.612, < 0.001) but not IL-4 ( = 0.325, = 0.053).
There was a high prevalence of vitamin D deficiency and insufficiency in infants with AD, and a low vitamin D level was correlated with the severity of AD, dependently on IL-17A.
特应性皮炎（AD）是一种免疫介导的炎症性皮肤病，通常在婴儿期发病。评估维生素D在AD免疫机制中作用的研究结果各异。
评估AD婴儿血清维生素D、细胞因子谱与疾病严重程度之间的关联。
在印度尼西亚赛富安瓦尔医院儿科过敏与免疫科对0至12个月的AD婴儿进行了一项横断面研究。通过特应性皮炎评分（SCORAD）指数评估疾病严重程度。抽取血液以评估嗜酸性粒细胞总数（TEC）、总免疫球蛋白E（tIgE）、25-羟基维生素D（25(OH)D）、白细胞介素-4（IL-4）、IL-17A和IL-22水平。
本研究纳入了36名婴儿，其中19名患有轻度AD，17名患有中度AD。分别在18名（50%）和9名（25%）受试者中发现维生素D缺乏和不足。中度AD组的平均25(OH)D水平较低，而平均IL-4、IL-17A和IL-22水平高于轻度AD组（<0.05）。较低的25(OH)D水平与较高的IL-17A水平相关（=-0.315，=0.041）。SCORAD指数与25(OH)D呈负相关（=-0.714，<0.001），与IL-17A呈正相关（=0.522，=0.001），与IL-22呈正相关（=0.612，<0.001），但与IL-4无相关性（=0.325，=0.053）。
AD婴儿中维生素D缺乏和不足的患病率较高，低维生素D水平与AD的严重程度相关，且依赖于IL-17A。
