Bakchine S, Lacomblez L, Benoit N, Parisot D, Chain F, Lhermitte F
Service de Neurologie et Neuropsychologie, Hôpital de la Salpêtriére France.
Neurology. 1989 Jun;39(6):777-81. doi: 10.1212/wnl.39.6.777.
A manic-like state occurred in a 44-year-old right-handed woman with bilateral orbitofrontal and right temporoparietal traumatic contusions. In a brief trial, we assessed the effect of clonidine, carbamazepine, dopa therapy, and placebo on manic symptoms and cognitive functions. Clonidine rapidly reversed the manic syndrome. The patient's behavior did not change with carbamazepine and worsened with levodopa. We suggest that the manic-like syndrome was related to noradrenergic overactivity secondary to the fronto-orbital lesions.
一名44岁右利手女性出现类躁狂状态，伴有双侧眶额叶及右侧颞顶叶创伤性挫伤。在一个简短的试验中，我们评估了可乐定、卡马西平、多巴疗法及安慰剂对躁狂症状和认知功能的影响。可乐定迅速逆转了躁狂综合征。卡马西平未改变患者的行为，而左旋多巴使症状恶化。我们认为，这种类躁狂综合征与额叶眶部病变继发的去甲肾上腺素能活动过度有关。
