Ruiz-Pérez Daniel, Largo Carlota, García-Río Francisco
Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, España.
Servicio de Neumología, Hospital Universitario La Paz, IdiPAZ, Madrid, España; Facultad de Medicina, Universidad Autónoma de Madrid, Madrid, España; CIBER de Enfermedades Respiratorias (CIBERES), España.
Arch Bronconeumol. 2016 Dec;52(12):596-604. doi: 10.1016/j.arbres.2016.04.008. Epub 2016 May 31.
In recent years, the number of lung transplantations performed as the last option for many respiratory diseases has grown considerably, both in adults and children. However, the causes for the relatively short survival of lungs compared to other organ transplants still need to be studied. Techniques have improved since the 1950s when experimental lung transplantation began, and the different animal species used now include rodents. The advantage of using these small species is that the surgical model has been expanded and standardized, and different respiratory problems can be studied. In this review we examine the different technical strategies used in experimental transplantation in rats and mice, focusing on surgical techniques and anesthesia and monitoring methods, and highlighting the major contributions of mouse lung transplantation to the field.
近年来，作为许多呼吸系统疾病的最终治疗选择，肺移植的数量在成人和儿童中都有显著增长。然而，与其他器官移植相比，肺的相对较短生存期的原因仍有待研究。自20世纪50年代实验性肺移植开始以来，技术已经有所改进，现在使用的不同动物物种包括啮齿动物。使用这些小型物种的优点是手术模型得到了扩展和标准化，可以研究不同的呼吸问题。在这篇综述中，我们研究了大鼠和小鼠实验性移植中使用的不同技术策略，重点关注手术技术、麻醉和监测方法，并突出了小鼠肺移植对该领域的主要贡献。
