Petrella V, Cantone P A, Alciato P, Gagliardini R, Fico D
U.S.L. n. 49, Ospedale di Varallo Sesia, Divisione di Medicina Generale.
Minerva Med. 1989 Apr;80(4):389-92.
The spread of cytostatics has made the search for safe drugs for the prevention and treatment of induced vomiting important. In the present study, the protective (prophylactic and therapeutic) effect of Alizapride has been examined. Ten oncological patients of average age 60 were treated with a total of 30 cycles according to the commonest protocols of drugs with varying emetic potential (from bland bleomycin type to high cisplatin type). The patients were subdivided into two groups: a) prophylaxis before and after chemotherapy; b) treatment only as needed. Analysis of the data showed excellent tolerance and significant effectiveness in both groups.
细胞抑制剂的广泛应用使得寻找预防和治疗诱导性呕吐的安全药物变得尤为重要。在本研究中，已对阿立必利的保护作用（预防性和治疗性）进行了检测。根据不同致吐潜力药物（从温和的博来霉素类型到高致吐性的顺铂类型）的最常见方案，对10名平均年龄为60岁的肿瘤患者共进行了30个周期的治疗。患者被分为两组：a）化疗前后的预防组；b）仅按需治疗组。数据分析表明两组患者均具有良好的耐受性和显著的疗效。
