Vanacker B, Van Aken H
Department of Anesthesiology, Katholieke Universiteit Leuven, Belgium.
Acta Anaesthesiol Belg. 1988;39(4):247-50.
Alizapride 50 mg intravenously was compared with placebo in a double-blind trial on 170 women undergoing planned soft tissue surgery under general anesthesia. Alizapride or placebo was given intravenously about 20 minutes before the end of the operation. A second and a third prophylactic dose was administered 4 and 8 hours after the first injection. The patients were observed for 24 hours postoperatively. A therapeutic dose of alizapride 50 mg was administered intravenously in the two groups if retching or emesis occurred in the postoperative period. In the alizapride group there was less retching or emesis than in the placebo-group and the difference was statistically significant. However, there was still a significant incidence of 34% of postoperative vomiting in the alizapride group. There were no effects on heart rate or on respiratory rate but small changes of blood pressure after the first and second prophylactic injection of alizapride have been noted.
在一项针对170名接受全身麻醉下计划性软组织手术的女性进行的双盲试验中，将静脉注射50毫克阿立必利与安慰剂进行了比较。阿立必利或安慰剂在手术结束前约20分钟静脉注射。在首次注射后4小时和8小时给予第二剂和第三剂预防性剂量。术后对患者观察24小时。如果术后发生干呕或呕吐，则在两组中静脉注射50毫克阿立必利的治疗剂量。阿立必利组的干呕或呕吐比安慰剂组少，差异具有统计学意义。然而，阿立必利组术后呕吐的发生率仍高达34%，具有显著性。对心率或呼吸频率没有影响，但在首次和第二次预防性注射阿立必利后，血压有微小变化。
