Herregodts P, Michotte Y, Ebinger G
Department of Neurology, Vrije Universiteit Brussel, Belgium.
Neurosci Lett. 1989 Apr 10;98(3):321-6. doi: 10.1016/0304-3940(89)90422-9.
We performed neurochemical quantitation of the catecholamines dopamine (DA), norepinephrine (NE) and epinephrine (E) and their major metabolites 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) in 22 cortical regions of 6 postmortem human brains. Statistical analysis indicated a clear regional difference for NE and E while DA and all the metabolites under study are homogeneously distributed over the cortex. These consistent regional differences suggest the possible role of NE and E as neurotransmitters or neuromodulators in human cerebral cortex.
我们对6例死后人类大脑的22个皮质区域中的儿茶酚胺多巴胺（DA）、去甲肾上腺素（NE）和肾上腺素（E）及其主要代谢产物3,4-二羟基苯乙酸（DOPAC）、高香草酸（HVA）和3-甲氧基-4-羟基苯乙二醇（MHPG）进行了神经化学定量分析。统计分析表明，NE和E存在明显的区域差异，而DA和所有研究的代谢产物在皮质中分布均匀。这些一致的区域差异表明NE和E可能作为人类大脑皮质中的神经递质或神经调节剂发挥作用。
