Li Xiaoxuan, Wang Yong
Department of Chemical Engineering, Chengde Petroleum College, Chengde, Hebei, People's Republic of China.
Tianjin Key Laboratory of Molecular Optoelectronic Science, Department of Chemistry, School of Science, Tianjin University, Tianjin, People's Republic of China.
Methods Mol Biol. 2019;1985:159-169. doi: 10.1007/978-1-4939-9438-0_9.
As one of the commonly used chiral separation materials, cyclodextrin-based chiral stationary phases (CD-CSP) have been developed rapidly in the past 30 years. A large number of CD-CSPs have been designed and applied for enantioseparation in high-performance liquid chromatography (HPLC). The development of novel CD-CSPs focuses on two aspects: the immobilization chemistry and the functionalization of the CD skeleton. Although such studies are not regarded as the prime research topic in analytical chemistry, there are still many recent works pushing this research forward tardily. In this chapter, the fabrication procedure of a triazole-bridged duplex CD-CSP and its application to HPLC enantioseparations is described.
作为常用的手性分离材料之一，基于环糊精的手性固定相（CD-CSP）在过去30年中得到了迅速发展。大量的CD-CSP已被设计并应用于高效液相色谱（HPLC）中的对映体分离。新型CD-CSP的发展集中在两个方面：固定化化学和CD骨架的功能化。尽管此类研究不被视为分析化学中的主要研究课题，但仍有许多近期工作在缓慢地推动这一研究向前发展。在本章中，描述了一种三唑桥连双环糊精手性固定相的制备过程及其在HPLC对映体分离中的应用。
