HPLC Enantioseparation on Cyclodextrin-Based Chiral Stationary Phases.

As one of the commonly used chiral separation materials, cyclodextrin-based chiral stationary phases (CD-CSP) have been developed rapidly in the past 30 years. A large number of CD-CSPs have been designed and applied for enantioseparation in high-performance liquid chromatography (HPLC). The development of novel CD-CSPs focuses on two aspects: the immobilization chemistry and the functionalization of the CD skeleton. Although such studies are not regarded as the prime research topic in analytical chemistry, there are still many recent works pushing this research forward tardily. In this chapter, the fabrication procedure of a triazole-bridged duplex CD-CSP and its application to HPLC enantioseparations is described.