Davies R, Gosling R J, Wales A D, Smith R P
Department of Bacteriology and Food Safety, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
Department of Bacteriology and Food Safety, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK.
Comp Immunol Microbiol Infect Dis. 2016 Jun;46:7-15. doi: 10.1016/j.cimid.2016.03.005. Epub 2016 Mar 24.
The study examined the effects of a licensed live Salmonella Typhimurium vaccine, administered to sows and gilts on three commercial pig units experiencing clinical salmonellosis associated with S. Typhimurium or its monophasic variant. After vaccination, clinical salmonellosis resolved and shedding of S. Typhimurium declined markedly and persistently on all breeding or breeding-finishing units, during the one- to two-year monitoring period. On two finishing units supplied in part by one of the vaccinated herds, pigs from the vaccinated herd were less likely to shed Salmonella than those from non-vaccinating herds, and Salmonella counts in faeces were also lower from the vaccine-linked animals. Non-Typhimurium Salmonella serovars were isolated typically in fewer than 10% of samples, and showed no clear temporal changes in frequency. Vaccination of dams alone with S. Typhimurium was associated with reduced shedding of closely-related serovars among all age groups in this commercial setting.
该研究考察了一种许可使用的活鼠伤寒沙门氏菌疫苗对三个出现与鼠伤寒沙门氏菌或其单相变体相关临床沙门氏菌病的商业养猪场的母猪和后备母猪的影响。接种疫苗后，在一到两年的监测期内，所有繁殖或繁殖育肥单元的临床沙门氏菌病均得到缓解，鼠伤寒沙门氏菌的排菌量显著且持续下降。在部分由其中一个接种疫苗的猪群供应猪只的两个育肥单元中，来自接种疫苗猪群的猪比未接种疫苗猪群的猪排菌的可能性更小，且与疫苗相关的猪的粪便中沙门氏菌数量也更低。非鼠伤寒沙门氏菌血清型通常在不到10%的样本中分离得到，且其频率没有明显的时间变化。在这种商业环境中，仅用鼠伤寒沙门氏菌对母猪进行疫苗接种与所有年龄组中密切相关血清型的排菌量减少有关。
