Department of Epidemiological Sciences, Animal and Plant Health Agency (APHA-Weybridge), New Haw, Addlestone, Surrey, UK.
Department of Bacteriology and Food Safety, Animal and Plant Health Agency (APHA-Weybridge), New Haw, Addlestone, Surrey, UK.
J Appl Microbiol. 2018 Jan;124(1):274-285. doi: 10.1111/jam.13609. Epub 2017 Nov 27.
The control of Salmonella in pig production is necessary for public and animal health, and vaccination was evaluated as a strategy to decrease pig prevalence.
The study examined the efficacy of a live Salmonella Typhimurium vaccine, administered to sows on eight commercial farrow-to-finish herds experiencing clinical salmonellosis or Salmonella carriage associated with S. Typhimurium or its monophasic variants. Results of longitudinal Salmonella sampling were compared against eight similarly selected and studied control farms. At the last visit (~14 months after the start of vaccination), when all finishing stock had been born to vaccinated sows, both faecal shedding and environmental prevalence of Salmonella substantially declined on the majority of vaccinated farms in comparison to the controls. A higher proportion of vaccine farms resolved clinical salmonellosis than controls. However, Salmonella counts in positive faeces samples were similar between nonvaccinated and vaccinated herds.
The results suggest that maternal vaccination is a suitable option for a Salmonella Typhimurium reduction strategy in farrow-to-finish pig herds.
Salmonella vaccines have the potential to reduce the prevalence of Salmonella in pigs and result in a reduction of human cases attributed to pork.
控制猪生产中的沙门氏菌对公共卫生和动物健康是必要的，疫苗接种被评估为降低猪群流行率的策略。
本研究评估了一种活的鼠伤寒沙门氏菌疫苗在 8 个商业化的育肥-出栏猪群中的功效，这些猪群在临床沙门氏菌病或与鼠伤寒沙门氏菌或其单相变体相关的沙门氏菌携带方面存在问题。对纵向沙门氏菌采样的结果与 8 个类似选择和研究的对照组农场进行了比较。在最后一次访问（接种开始后约 14 个月）时，所有育肥猪都来自接种过疫苗的母猪，与对照组相比，大多数接种疫苗的农场的粪便排泄和环境中沙门氏菌的流行率都大幅下降。与对照组相比，更多的疫苗接种农场解决了临床沙门氏菌病问题。然而，在阳性粪便样本中，未接种疫苗和接种疫苗的畜群的沙门氏菌计数相似。
结果表明，母猪接种疫苗是育肥-出栏猪群中减少鼠伤寒沙门氏菌的一种可行选择。
沙门氏菌疫苗有可能降低猪群中沙门氏菌的流行率，并减少归因于猪肉的人类病例。
