Golla Sandeep S V, Boellaard Ronald, Oikonen Vesa, Hoffmann Anja, van Berckel Bart N M, Windhorst Albert D, Virta Jere, Te Beek Erik T, Groeneveld Geert Jan, Haaparanta-Solin Merja, Luoto Pauliina, Savisto Nina, Solin Olof, Valencia Ray, Thiele Andrea, Eriksson Jonas, Schuit Robert C, Lammertsma Adriaan A, Rinne Juha O
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands
Department of Radiology and Nuclear Medicine, VU University Medical Center, Amsterdam, The Netherlands.
J Nucl Med. 2016 Oct;57(10):1543-1547. doi: 10.2967/jnumed.116.173013. Epub 2016 Jun 3.
F-labeled N,N-diethyl-2-(2-[4-(2-fluoroethoxy)phenyl]-5,7-dimethylpyrazolo[1,5-α]pyrimidine-3-yl)acetamide (DPA-714) is a radioligand for the 18-kDa translocator protein. The purpose of the present study was to identify the best method for generating quantitative parametric images of F-DPA-714 binding.
Ninety-minute dynamic F-DPA-714 PET scans with full arterial sampling from 6 healthy subjects and 9 Alzheimer disease (AD) patients were used. Plasma-input-based Logan graphical analysis and spectral analysis were used to generate parametric volume of distribution (V) images. Five versions of Ichise, reference Logan, and 2 basis function implementations (receptor parametric mapping and simplified reference tissue model 2 [SRTM2]) of SRTM, all using gray matter cerebellum as the reference region, were applied to generate nondisplaceable binding potential (BP) images.
Plasma-input Logan analysis (r = 0.99; slope, 0.88) and spectral analysis (r = 0.99, slope, 0.93) generated estimates of V that correlated well with values obtained using nonlinear regression. BP values generated using SRTM2 (r = 0.83; slope, 0.95) and reference Logan analysis (r = 0.88; slope, 1.01) correlated well with nonlinear regression-based estimates.
Both Logan analysis and spectral analysis can be used to obtain quantitatively accurate V images of F-DPA-714. In addition, SRTM2 and reference Logan analysis can provide accurate BP images. These parametric images could be used for voxel-based comparisons.
F 标记的 N,N-二乙基-2-(2-[4-(2-氟乙氧基)苯基]-5,7-二甲基吡唑并[1,5-α]嘧啶-3-基)乙酰胺（DPA-714）是一种用于 18 kDa 转位蛋白的放射性配体。本研究的目的是确定生成 F-DPA-714 结合定量参数图像的最佳方法。
对 6 名健康受试者和 9 名阿尔茨海默病（AD）患者进行了 90 分钟的动态 F-DPA-714 PET 扫描，并进行全动脉采样。基于血浆输入的 Logan 图形分析和频谱分析用于生成分布容积（V）参数图像。应用了 Ichise 的五个版本、参考 Logan 分析以及 SRTM 的两种基函数实现（受体参数映射和简化参考组织模型 2 [SRTM2]），所有这些都使用小脑灰质作为参考区域，以生成不可置换结合潜能（BP）图像。
血浆输入的 Logan 分析（r = 0.99；斜率，0.88）和频谱分析（r = 0.99，斜率，0.93）生成的 V 估计值与使用非线性回归获得的值具有良好的相关性。使用 SRTM2（r = 0.83；斜率，0.95）和参考 Logan 分析（r = 0.88；斜率，1.01）生成的 BP 值与基于非线性回归的估计值具有良好的相关性。
Logan 分析和频谱分析均可用于获得 F-DPA-714 的定量准确 V 图像。此外，SRTM2 和参考 Logan 分析可以提供准确的 BP 图像。这些参数图像可用于基于体素的比较。
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