在一台市售的放射性合成仪 Elixys Flex/Chem 上自动化合成 [F]DPA-714。
An automated radiosynthesis of [F]DPA-714 on a commercially available radiosynthesizer, Elixys Flex/Chem.
机构信息
Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA, USA.
Department of Chemistry, University of Virginia, Charlottesville, VA, USA.
出版信息
Appl Radiat Isot. 2022 Feb;180:110032. doi: 10.1016/j.apradiso.2021.110032. Epub 2021 Nov 18.
Abstract
[F]DPA-714 is a radiotracer specific to the translocator protein (TSPO) and is useful for in vivo Positron Emission Tomography imaging studies. In this report, we have developed an automated radiosynthesis of [F]DPA-714 on a commercially-available radiosynthesis platform, which comports with USP <823> guidelines. The wide availability of the radiosynthesis module and ease of dissemination of the production sequence will facilitate preclinical and clinical research of TSPO-related pathology.
摘要
[F]DPA-714 是一种专门针对转位蛋白（TSPO）的放射性示踪剂，可用于体内正电子发射断层扫描成像研究。在本报告中，我们在商业上可用的放射性合成平台上开发了 [F]DPA-714 的自动化放射性合成，符合 USP <823> 指南。放射性合成模块的广泛可用性和生产序列的易于传播将促进 TSPO 相关病理学的临床前和临床研究。
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