Department of Pharmacology and Therapeutic, State University of Maringá, Paraná, Brazil.
Department of Biochemistry, State University of Maringá, Paraná, Brazil.
Asian Pac J Trop Med. 2016 May;9(5):432-6. doi: 10.1016/j.apjtm.2016.03.033. Epub 2016 Mar 23.
To evaluate the effect of hydroethanolic extract of yacon on the hyperglycemia induced by streptozotocin (STZ) in neonatal rats.
Wistar rats aged two days old received an intraperitoneal injection of STZ (160 mg/kg); after seven weeks, glycosuria was determined and animals with glucose levels above 250 mg/dL were included in the study. Groups of diabetic and non-diabetic rats were treated orally with yacon extract at a dose of 400 mg/kg/d for 14 d. Tests were made for phytochemical characterization, glucose tolerance and toxicity.
The results showed that treatment with the extract reduced the glucose levels of fed diabetic rats and did not change the glucose levels of fasting diabetic and normal rats. Additionally, also it was observed that treatment with the extract reduced blood glucose levels of diabetic rats during the oral and intravenous glucose tolerance tests. There was no change in body weight, liver enzymes or mortality with yacon extract treatment. The phytochemical screening revealed the presence of caffeic acid, chlorogenic acid, ferulic acid and gallic acid.
The data suggest that yacon extract reduces hyperglycemia, possibly by improving insulin sensibility through its phytochemicals constituents (phenolic compounds).
评估雅可比乙醇提取物对链脲佐菌素（STZ）诱导的新生大鼠高血糖的影响。
2 天大的 Wistar 大鼠腹腔注射 STZ（160mg/kg）；7 周后，检测尿糖，将血糖水平超过 250mg/dL 的动物纳入研究。糖尿病和非糖尿病大鼠分别用雅可比提取物（剂量为 400mg/kg/d）口服治疗 14d。进行植物化学特征、葡萄糖耐量和毒性测试。
结果表明，提取物治疗降低了进食的糖尿病大鼠的血糖水平，而不改变禁食的糖尿病和正常大鼠的血糖水平。此外，还观察到提取物治疗降低了口服和静脉葡萄糖耐量试验中糖尿病大鼠的血糖水平。雅可比提取物治疗未改变体重、肝酶或死亡率。植物化学筛选显示存在咖啡酸、绿原酸、阿魏酸和没食子酸。
数据表明，雅可比提取物可降低高血糖，可能通过其植物化学成分（酚类化合物）改善胰岛素敏感性。
