Dos Santos Klinsmann Carolo, Bueno Bianca Guerra, Pereira Luana Ferreira, Francisqueti Fabiane Valentini, Braz Mariana Gobbo, Bincoleto Lahis Fernandes, da Silva Lilian Xavier, Ferreira Ana Lúcia A, Nakamune Ana Cláudia de Melo Stevanato, Chen C-Y Oliver, Blumberg Jeffrey B, Corrêa Camila Renata
São Paulo State University (UNESP), Medical School, Botucatu, SP, Brazil.
Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.
Evid Based Complement Alternat Med. 2017;2017:6418048. doi: 10.1155/2017/6418048. Epub 2017 Jul 20.
The effects of hydroethanolic extract of Yacon leaves (HEYL) on antioxidant, glycemic, and inflammatory biomarkers were tested in diabetic rats. Outcome parameters included glucose, insulin, interleukin-6 (IL-6), and hydrophilic antioxidant capacity (HAC) in serum and IL-6, HAC, malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in soleus. The rats (10/group) were divided as follows: C, controls; C + Y, HEYL treated; DM, diabetic controls; and DM + Y, diabetic rats treated with HEYL. Diabetes mellitus was induced by administration of streptozotocin. C + Y and DM + Y groups received 100 mg/kg HEYL daily via gavage for 30 d. Hyperglycemia was improved in the DM + Y versus DM group. Insulin was reduced in DM versus C group. DM rats had higher IL-6 and MDA and lower HAC in the soleus muscle. HEYL treatment decreased IL-6 and MDA and increased HAC in DM rats. DM + Y rats had the highest CAT activity versus the other groups; GPx was higher in C + Y and DM + Y versus their respective controls. The apparent benefit of HEYL may be mediated via improving glucoregulation and ameliorating oxidative stress and inflammation, particularly in diabetic rats.
在糖尿病大鼠中测试了雪莲果叶水乙醇提取物（HEYL）对抗氧化、血糖和炎症生物标志物的影响。结果参数包括血清中的葡萄糖、胰岛素、白细胞介素-6（IL-6）和亲水抗氧化能力（HAC），以及比目鱼肌中的IL-6、HAC、丙二醛（MDA）、超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）。大鼠（每组10只）分为以下几组：C组，对照组；C + Y组，HEYL处理组；DM组，糖尿病对照组；DM + Y组，用HEYL处理的糖尿病大鼠组。通过注射链脲佐菌素诱导糖尿病。C + Y组和DM + Y组每天通过灌胃给予100 mg/kg HEYL，持续30天。与DM组相比，DM + Y组的高血糖得到改善。与C组相比，DM组的胰岛素水平降低。DM大鼠比目鱼肌中的IL-6和MDA较高，HAC较低。HEYL处理降低了DM大鼠的IL-6和MDA水平，并提高了HAC。与其他组相比，DM + Y组大鼠的CAT活性最高；与各自的对照组相比，C + Y组和DM + Y组的GPx水平较高。HEYL的明显益处可能是通过改善血糖调节、减轻氧化应激和炎症来介导的，尤其是在糖尿病大鼠中。
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