Ito Takuya, Nisa Khoirun, Kodama Takeshi, Tanaka Masami, Okamoto Yasuko, Morita Hiroyuki
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan.
Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan; Research Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences (LIPI), Jl. Jogja-Wonosari Km. 32, Playen, Gunungkidul, Yogyakarta 55861, Indonesia.
Fitoterapia. 2016 Jul;112:132-5. doi: 10.1016/j.fitote.2016.05.017. Epub 2016 Jun 2.
Two new cyclopentenones, frutescencenones A (1) and B (2), and a new furanone derivative, frutescencenone C (3), together with two known cyclopentenones (4 and 5), were isolated from the leaves of Baeckea frutescens. Their structures were deduced by comprehensive spectroscopic analyses, including 1D and 2D NMR, and HREIMS data. Frutescencenone A (1) showed moderate growth inhibitory activity against human lung A549, pancreatic PSN-1, and breast MDA-MB-231 cancer cell lines, with IC50 values of 36.3μM, 38.2μM, and 29.3μM, respectively. In contrast, frutescencenone C (3) showed selective cytotoxic activity against PSN-1, with an IC50 value of 20.1μM.
从岗松（Baeckea frutescens）叶中分离得到两个新的环戊烯酮类化合物，岗松烯酮A（1）和岗松烯酮B（2），以及一个新的呋喃酮衍生物，岗松烯酮C（3），同时还得到两个已知的环戊烯酮类化合物（4和5）。通过包括一维和二维核磁共振以及高分辨电子轰击质谱数据在内的综合光谱分析推导了它们的结构。岗松烯酮A（1）对人肺癌A549、胰腺PSN-1和乳腺癌MDA-MB-231细胞系显示出中等程度的生长抑制活性，IC50值分别为36.3μM、38.2μM和29.3μM。相比之下，岗松烯酮C（3）对PSN-1显示出选择性细胞毒性活性，IC50值为20.1μM。
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