Bergers Lambert I J C, Reijnders Christianne M A, van den Broek Lenie J, Spiekstra Sander W, de Gruijl Tanja D, Weijers Ester M, Gibbs Susan
Department of Dermatology, VU University Medical Center, Amsterdam, The Netherlands.
Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands.
Drug Discov Today. 2016 Sep;21(9):1479-1488. doi: 10.1016/j.drudis.2016.05.008. Epub 2016 Jun 2.
All skin diseases have an underlying immune component. Owing to differences in animal and human immunology, the majority of drugs fail in the preclinical or clinical testing phases. Therefore animal alternative methods that incorporate human immunology into in vitro skin disease models are required to move the field forward. This review summarizes the progress, using examples from fibrosis, autoimmune diseases, psoriasis, cancer and contact allergy. The emphasis is on co-cultures and 3D organotypic models. Our conclusion is that current models are inadequate and future developments with immune-competent skin-on-chip models based on induced pluripotent stem cells could provide a next generation of skin models for drug discovery and testing.
所有皮肤疾病都有潜在的免疫成分。由于动物和人类免疫学存在差异，大多数药物在临床前或临床试验阶段失败。因此，需要将人类免疫学纳入体外皮肤疾病模型的动物替代方法来推动该领域的发展。本综述以纤维化、自身免疫性疾病、银屑病、癌症和接触性过敏为例，总结了相关进展。重点是共培养和三维器官型模型。我们的结论是，当前模型存在不足，基于诱导多能干细胞的具有免疫活性的芯片上皮肤模型的未来发展可为药物发现和测试提供下一代皮肤模型。
