Aazmi Abdellah, Zhang Duo, Mazzaglia Corrado, Yu Mengfei, Wang Zhen, Yang Huayong, Huang Yan Yan Shery, Ma Liang
State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University, Hangzhou, 310058, China.
School of Mechanical Engineering, Zhejiang University, Hangzhou, 310058, China.
Bioact Mater. 2023 Sep 9;31:475-496. doi: 10.1016/j.bioactmat.2023.08.018. eCollection 2024 Jan.
In the human body, almost all cells interact with extracellular matrices (ECMs), which have tissue and organ-specific compositions and architectures. These ECMs not only function as cellular scaffolds, providing structural support, but also play a crucial role in dynamically regulating various cellular functions. This comprehensive review delves into the examination of biofabrication strategies used to develop bioactive materials that accurately mimic one or more biophysical and biochemical properties of ECMs. We discuss the potential integration of these ECM-mimics into a range of physiological and pathological models, enhancing our understanding of cellular behavior and tissue organization. Lastly, we propose future research directions for ECM-mimics in the context of tissue engineering and organ-on-a-chip applications, offering potential advancements in therapeutic approaches and improved patient outcomes.
在人体中，几乎所有细胞都与细胞外基质（ECM）相互作用，这些细胞外基质具有组织和器官特异性的组成和结构。这些细胞外基质不仅作为细胞支架发挥作用，提供结构支撑，还在动态调节各种细胞功能方面发挥关键作用。这篇全面的综述深入探讨了用于开发能够精确模拟细胞外基质一种或多种生物物理和生化特性的生物活性材料的生物制造策略。我们讨论了这些细胞外基质模拟物在一系列生理和病理模型中的潜在整合，增进了我们对细胞行为和组织组织的理解。最后，我们提出了在组织工程和芯片器官应用背景下细胞外基质模拟物的未来研究方向，为治疗方法的潜在进步和改善患者预后提供了可能。
