Department of Nanomedicine, Houston Methodist Research Institute, Houston, Texas, USA; Texas A&M University School of Medicine, College Station, Texas, USA.
Texas A&M University School of Medicine, College Station, Texas, USA.
J Invest Dermatol. 2024 Aug;144(8):1707-1715. doi: 10.1016/j.jid.2024.01.031. Epub 2024 Mar 16.
Skin-on-a-chip (SoC) technologies are emerging as a paradigm shift in dermatology research by replicating human physiology in a dynamic manner not achievable by current animal models. Although animal models have contributed to successful clinical trials, their ability to predict human outcomes remains questionable, owing to inherent differences in skin anatomy and immune response. Covering areas including infectious diseases, autoimmune skin conditions, wound healing, drug toxicity, aging, and antiaging, SoC aims to circumvent the inherent disparities created by traditional models. In this paper, we review current SoC technologies, highlighting their potential as an alternative to animal models for a deeper understanding of complex skin conditions.
皮肤芯片（SoC）技术正在成为皮肤病学研究的范式转变，以动态方式复制人体生理学，这是当前动物模型无法实现的。尽管动物模型为成功的临床试验做出了贡献，但由于皮肤解剖结构和免疫反应的固有差异，它们预测人类结果的能力仍然存在疑问。SoC 涵盖了传染病、自身免疫性皮肤病、伤口愈合、药物毒性、衰老和抗衰老等领域，旨在避免传统模型带来的固有差异。本文综述了当前的 SoC 技术，强调了它们作为动物模型替代品的潜力，以更深入地了解复杂的皮肤状况。
