有证据表明肿瘤抗原通过与放射敏感（抑制性？）细胞群体相互作用在体内促进肿瘤生长。
Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population.
作者信息
Hellström K E, Hellström I
出版信息
Proc Natl Acad Sci U S A. 1978 Jan;75(1):436-40. doi: 10.1073/pnas.75.1.436.
Abstract
The growth of a small number of cells from each of two chemically induced BALB/c sarcomas was enhanced when x-irradiated (15,000 rads) cells of the same sarcoma were mixed with the tumor inoculum. This enhancement did not occur if the recipients had been given a total body x-irradiation of 450 rads. Tumor neutralization (Winn) tests showed that tumor cells irradiated in vitro enhanced tumor growth only in the presence of radiosensitive cells present in the spleens of both nonimmune and tumor-bearing mice. On the basis of these findings we postulate that tumor antigen blocks effective tumor immunity by a mechanism that involves a suppressor cell population.
摘要
当将同一化学诱导的BALB/c肉瘤经X射线照射（15,000拉德）后的细胞与肿瘤接种物混合时，来自两种化学诱导的BALB/c肉瘤的少量细胞的生长得到了增强。如果受体接受了450拉德的全身X射线照射，则不会出现这种增强现象。肿瘤中和（温恩）试验表明，体外照射的肿瘤细胞仅在非免疫小鼠和荷瘤小鼠脾脏中存在的放射敏感细胞存在的情况下才会增强肿瘤生长。基于这些发现，我们推测肿瘤抗原通过一种涉及抑制细胞群体的机制来阻断有效的肿瘤免疫。
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