Vorsters Alex, Cornelissen Tine, Leuridan Elke, Bogers Johannes, Vanden Broeck Davy, Benoy Ina, Goossens Herman, Hens Niel, Van Damme Pierre
Centre for the Evaluation of Vaccination (CEV), Vaccine and Infectious Disease Institute (VAXINFECTIO), University of Antwerp, Campus Drie Eiken, Universiteitsplein 1, B 2610, Antwerp, Belgium.
Antwerp Health House for Prostitution, Ghapro vzw, Antwerp, Belgium.
BMC Public Health. 2016 Jun 7;16:477. doi: 10.1186/s12889-016-3099-5.
Although female sex workers (FSWs) are a well-known high-risk group for Human Papillomavirus (HPV) infections, few tailored intervention programmes for HPV have been established worldwide. The lack of reliable data on the prevalence of HPV and related cervical lesions hampers the establishment of evidence-based intervention programmes. The objectives of this study were to describe the prevalence of high-risk Human Papillomavirus (hrHPV) infections and abnormal pap smears in FSWs compared to a control group in Antwerp, Belgium.
HPV genotyping and cytology data were analysed from routine Pap smear tests that were collected from both FSWs and the general population (1334 samples for each group) between June 2006 and June 2010. Within the laboratory database, all FSWs were matched 1:1 for age and testing date to determine the ORs of hrHPV genotypes, DNA and cytology outcome.
The prevalence of hrHPV DNA in FSWs was 41.7 % compared to 19.8 % in the age-matched controls with an overall OR of 2.8 (95 % CI: 2.3-3.4). Significant differences were observed in all age groups, and the most significant differences were observed in the cohort under 21 years of age (prevalence of 64.4 % in FSWs versus 14.8 % in controls; OR 10.3 (95 % CI: 5.0-21.2). Significantly more cervical lesions were observed in FSWs, particularly in the 17- to 21-year old age group (OR for LSIL or HSIL: 10.3 (95 % CI: 3.2-33.8). In both groups, HPV 16 was the most prevalent at 12.1 and 6.6 % in the FSW and control groups, respectively. HPV 18 was the 8(th) and 7(th) most frequent genotype at 5.0 and 2.5 % in the FSW and control groups, respectively.
FSWs have a significantly higher prevalence of hrHPV and more abnormal Pap smears than does the general population in Antwerp, Belgium. The hrHPV prevalence in FSWs is similar to that reported in the literature. The need for tailored intervention programmes should be investigated further.
尽管女性性工作者是众所周知的人乳头瘤病毒（HPV）感染高危人群，但全球范围内针对HPV的定制干预项目却很少。缺乏关于HPV流行率及相关宫颈病变的可靠数据阻碍了循证干预项目的建立。本研究的目的是描述比利时安特卫普女性性工作者与对照组相比高危人乳头瘤病毒（hrHPV）感染及异常巴氏涂片的流行情况。
分析了2006年6月至2010年6月期间从女性性工作者和普通人群（每组1334份样本）收集的常规巴氏涂片检查中的HPV基因分型和细胞学数据。在实验室数据库中，所有女性性工作者按年龄和检测日期1:1匹配，以确定hrHPV基因型、DNA和细胞学结果的比值比。
女性性工作者中hrHPV DNA的流行率为41.7%，而年龄匹配的对照组为19.8%，总体比值比为2.8（95%可信区间：2.3 - 3.4）。在所有年龄组中均观察到显著差异，在21岁以下队列中差异最为显著（女性性工作者中流行率为64.4%，对照组为14.8%；比值比10.3（95%可信区间：5.0 - 21.2）。女性性工作者中观察到的宫颈病变明显更多，尤其是在17至21岁年龄组（低度鳞状上皮内病变或高度鳞状上皮内病变的比值比：10.3（95%可信区间：3.2 - 33.）。在两组中，HPV 16最为常见，在女性性工作者组和对照组中分别为12.1%和6.6%。HPV 18在女性性工作者组和对照组中分别是第8和第7常见基因型，分别为5.0%和2.5%。
与比利时安特卫普的普通人群相比，女性性工作者中hrHPV的流行率显著更高，巴氏涂片异常情况更多。女性性工作者中hrHPV的流行率与文献报道相似。应进一步研究定制干预项目的必要性。
