人脑胃泌素样肽类物质生物活性的证明：其与胆囊收缩素羧基末端八肽的关系。
Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.
作者信息
Robberecht P, Deschodt-Lanckman M, Vanderhaeghen J J
出版信息
Proc Natl Acad Sci U S A. 1978 Jan;75(1):524-8. doi: 10.1073/pnas.75.1.524.
Abstract
The previously described peptide material that reacts with antibodies to gastrin and is found in the central nervous system of various vertebrates is present in only the 100,000 X g pellet of postmortem human cerebral cortical grey matter. This immunoreactive material, extractable in boiling water, is biologically active on rat pancreatic preparations. On the basis of size, charge, immunological specificity, and patterns of biological activity, most of this material is closely related to the COOH-terminal octapeptide of cholecystokinin in its complete, sulfated biologically active form.
摘要
先前描述的与胃泌素抗体发生反应且存在于各种脊椎动物中枢神经系统中的肽物质，仅存在于死后人类大脑皮质灰质经100,000 X g离心后的沉淀中。这种可在沸水中提取的免疫反应性物质对大鼠胰腺制剂具有生物活性。基于大小、电荷、免疫特异性和生物活性模式，这种物质中的大部分在其完整的、硫酸化的生物活性形式上与胆囊收缩素的COOH末端八肽密切相关。
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