Kandel Bishnu Prasad, Singh Yogendra Prasad, Ghimire Bikal
Department of Surgery, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu, Nepal E-mail :
Asian Pac J Cancer Prev. 2016;17(5):2695-7.
Gastric cancer, the fifth most common malignancy in the world, usually affects older individuals but can occur in younger age groups. In this study we compared the clinicopathological profile of young patients of gastric cancer with that of older patients.
It is a prospective study of gastric cancer patients treated over three year period (January 2012 to December 2014). Data of patients were obtained from the medical record. Clinical and pathological characters of younger patients (age 40 years or less) were compared with older patients (age more than 40 years).
There were total of 152 patients treated during the study period. Twenty patients (13.2%) were less than 40 years of age and 132 (86.8%) were older. The male to female ratio in younger patients was 1:1.5 whereas in older patients it was 1:0.6. In the younger age group 14 patients (70%) had poorly differentiated adenocarcinoma in contrast to 45% in the older age group (<0.01). Some 55% of younger and 42% of older patients had stage IV disease at presentation and curative surgery was not possible. Palliative surgery for gastric outlet obstruction or bleeding from the tumor was performed on 25% and 21% respectively.
Gastric cancer in young people aged less than 40 years has unique characters like female predominance, unfavorable tumor biology, and advanced stage at presentation. There should be a high index of suspicion of gastric cancer even in young patients.
胃癌是世界上第五大常见恶性肿瘤，通常影响老年人，但也可发生于较年轻的年龄组。在本研究中，我们比较了年轻胃癌患者与老年胃癌患者的临床病理特征。
这是一项对三年期间（2012年1月至2014年12月）接受治疗的胃癌患者的前瞻性研究。患者数据取自病历。将年轻患者（年龄40岁及以下）与老年患者（年龄超过40岁）的临床和病理特征进行比较。
研究期间共治疗了152例患者。20例患者（13.2%）年龄小于40岁，132例（86.8%）年龄较大。年轻患者的男女比例为1:1.5，而老年患者为1:0.6。在较年轻年龄组中，14例患者（70%）患有低分化腺癌，而老年组为45%（<0.01）。约55%的年轻患者和42%的老年患者在就诊时处于IV期疾病，无法进行根治性手术。分别有25%和21%的患者因胃出口梗阻或肿瘤出血接受了姑息性手术。
年龄小于40岁的年轻人患胃癌具有独特特征，如女性占优势、肿瘤生物学特性不佳以及就诊时处于晚期。即使是年轻患者，也应高度怀疑胃癌。
