铜催化的 N-芳基甘氨酸酯与末端炔烃的有氧对映选择性交叉脱氢偶联反应。
Copper-Catalyzed Aerobic Enantioselective Cross-Dehydrogenative Coupling of N-Aryl Glycine Esters with Terminal Alkynes.
机构信息
School of Pharmaceutical Sciences, Shandong University , Jinan 250012, China.
College of Chemistry and Chemical Engineering, Xuchang University , Xuchang 461000, China.
出版信息
Org Lett. 2016 Jun 17;18(12):2982-5. doi: 10.1021/acs.orglett.6b01328. Epub 2016 Jun 7.
PMID:27269737
Abstract
A copper-catalyzed enantioselective cross-coupling of a Csp3-H moiety (N-aryl glycine ester) with a Csp-H component (terminal alkyne) using molecular oxygen as the terminal oxidant is described for the first time. The sustainable method provides an efficient and environmentally friendly approach to rapidly prepare a diverse array of optically active non-natural α-amino acids.
摘要
首次描述了一种铜催化的 Csp3-H 部分（N-芳基甘氨酸酯）与 Csp-H 部分（末端炔烃）的对映选择性交叉偶联反应，使用分子氧作为末端氧化剂。这种可持续的方法为快速制备各种具有光学活性的非天然α-氨基酸提供了一种高效、环保的方法。
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