College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P.R. China) http://aiwenlei.whu.edu.cn/Main_Website/
College of Chemistry and Molecular Sciences, the Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei (P.R. China) http://aiwenlei.whu.edu.cn/Main_Website/.
Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15850-3. doi: 10.1002/anie.201509042. Epub 2015 Nov 13.
Because of the lack of redox ability, zinc has seldom been used as a catalyst in dehydrogenative cross-coupling reactions. Herein, a novel zinc-catalyzed dehydrogenative C(sp(2) )H/C(sp)H cross-coupling of terminal alkynes with aldehydes was developed, and provides a simple way to access ynones from readily available materials under mild reaction conditions. Good reaction selectivity can be achieved with a 1:1 ratio of terminal alkyne and aldehyde. Various terminal alkynes and aldehydes are suitable in this transformation.
由于缺乏氧化还原能力，锌很少被用作脱氢交叉偶联反应中的催化剂。在此，开发了一种新型的锌催化末端炔烃与醛的脱氢 C(sp(2) )H/C(sp)H 交叉偶联反应，为在温和的反应条件下从易得的原料中获得炔酮提供了一种简单的方法。在末端炔烃和醛的 1:1 比例下，可以实现良好的反应选择性。各种末端炔烃和醛都适用于这种转化。
