White J M
Department of Psychology, Monash University, Clayton, Victoria, Australia.
Pharmacol Biochem Behav. 1989 Feb;32(2):479-82. doi: 10.1016/0091-3057(89)90183-4.
Graded doses of nicotine (0.01-1.0 mg/kg) were administered alone and together with three doses of diazepam (0.3, 1.0 and 3.0 mg/kg) to rats responding on a fixed-interval 2-min schedule of liquid food reinforcement. Nicotine (0.03-1.0 mg/kg) increased overall rate, but diazepam had little effect. Both nicotine and the two highest doses of diazepam attenuated the change in response rate through the interval. When combined with nicotine the lowest dose of diazepam increased overall rates above those produced by nicotine alone. However, it appeared to diminish the effects of nicotine on the within-interval pattern of responding. These changes appeared to be due to an elevation in the high rates at the end of the interval. In contrast, the highest diazepam dose increased overall response rates when combined with low doses of nicotine, but decreased the high rates observed after larger nicotine doses. This dose of diazepam combined in an additive manner with nicotine to reduce the degree of response rate change within the interval. The interaction between nicotine and diazepam depends on the aspect of behavior under investigation and the particular doses of the two drugs.
给按照固定间隔2分钟液体食物强化程序做出反应的大鼠单独给予分级剂量的尼古丁（0.01 - 1.0毫克/千克），并同时给予三个剂量的地西泮（0.3、1.0和3.0毫克/千克）。尼古丁（0.03 - 1.0毫克/千克）提高了总体反应率，但地西泮影响不大。尼古丁和地西泮的两个最高剂量均减弱了整个间隔期内反应率的变化。与尼古丁合用时，地西泮的最低剂量使总体反应率高于单独使用尼古丁时产生的反应率。然而，它似乎减弱了尼古丁对间隔期内反应模式的影响。这些变化似乎是由于间隔期末期高反应率的升高所致。相比之下，地西泮的最高剂量与低剂量尼古丁合用时提高了总体反应率，但降低了较大剂量尼古丁后观察到的高反应率。该剂量的地西泮与尼古丁以相加的方式联合，以降低间隔期内反应率变化的程度。尼古丁和地西泮之间的相互作用取决于所研究行为的方面以及两种药物的具体剂量。
