Genovese R F, Elsmore T F
Department of Medical Neurosciences, Walter Reed Army Institute of Research, Washington, DC 20307-5100.
Pharmacol Biochem Behav. 1989 Feb;32(2):495-8. doi: 10.1016/0091-3057(89)90187-1.
The effects of the anticholinergic atropine and azaprophen, a novel, conformationally restricted analog of atropine, were examined in rhesus monkeys using delayed match-to-sample and detection tasks. Both compounds (0.01-0.32 mg/kg) produced dose-dependent decreases in the rate of responding under both tasks. Drug effects on the match-to-sample task correlated with drug effects on the detection task. Both compounds produced decreases in the percentage of correct responses on the match-to-sample task when choice trials occurred 4 or 16 sec, but not 0.01 sec, following sample presentation. Doses of atropine and azaprophen decreasing accuracy on the match-to-sample task also decreased the number of responses on the task. In general, atropine was slightly more potent than azaprophen on both tasks. These results further characterize azaprophen's anticholinergic effects.
使用延迟匹配样本和检测任务，在恒河猴中研究了抗胆碱能药物阿托品以及一种新型的、构象受限的阿托品类似物阿扎丙芬的作用。两种化合物（0.01 - 0.32毫克/千克）在两项任务中均产生了剂量依赖性的反应率下降。药物对匹配样本任务的影响与对检测任务的影响相关。当在呈现样本后4秒或16秒（而非0.01秒）进行选择试验时，两种化合物均使匹配样本任务的正确反应百分比降低。降低匹配样本任务准确性的阿托品和阿扎丙芬剂量也减少了该任务中的反应次数。总体而言，在两项任务中阿托品的效力略强于阿扎丙芬。这些结果进一步描述了阿扎丙芬的抗胆碱能作用。
