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中枢性与外周性抗胆碱能作用对行为链重复习得的影响

Central vs peripheral anticholinergic effects on repeated acquisition of behavioral chains.

作者信息

Levy A, Elsmore T F, Hursh S R

出版信息

Behav Neural Biol. 1984 Jan;40(1):1-4. doi: 10.1016/s0163-1047(84)90122-5.

DOI:10.1016/s0163-1047(84)90122-5
PMID:6732703
Abstract

Monkeys that were required to repeatedly learn new sequences of responses to obtain food were injected with 0.2 mg/kg of atropine sulfate or methylatropine nitrate. Effects lasted 8 to 12 hr following injection. Both drugs decreased the rate at which the animals worked, but only atropine sulfate increased the number of attempts required to solve the problem and decreased overall accuracy, suggesting a peripheral mode of action for rate-decreasing effects, and a central mode of action for effects of atropine on qualitative aspects of performance.

摘要

那些被要求反复学习新的反应序列以获取食物的猴子被注射了0.2毫克/千克的硫酸阿托品或硝酸甲基阿托品。注射后效果持续8至12小时。两种药物都降低了动物工作的速率,但只有硫酸阿托品增加了解决问题所需的尝试次数并降低了总体准确性,这表明速率降低效应的外周作用模式,以及阿托品对行为质量方面影响的中枢作用模式。

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