Campbell C L, Wood K, Brown C T A, Moseley H
School of Physics and Astronomy, University of St Andrews, UK.
Phys Med Biol. 2016 Jul 7;61(13):4840-54. doi: 10.1088/0031-9155/61/13/4840. Epub 2016 Jun 8.
We explore the effects of three dimensional (3D) tumour structures on depth dependent fluence rates, photodynamic doses (PDD) and fluorescence images through Monte Carlo radiation transfer modelling of photodynamic therapy. The aim with this work was to compare the commonly used uniform tumour densities with non-uniform densities to determine the importance of including 3D models in theoretical investigations. It was found that fractal 3D models resulted in deeper penetration on average of therapeutic radiation and higher PDD. An increase in effective treatment depth of 1 mm was observed for one of the investigated fractal structures, when comparing to the equivalent smooth model. Wide field fluorescence images were simulated, revealing information about the relationship between tumour structure and the appearance of the fluorescence intensity. Our models indicate that the 3D tumour structure strongly affects the spatial distribution of therapeutic light, the PDD and the wide field appearance of surface fluorescence images.
我们通过光动力疗法的蒙特卡罗辐射传输建模，探讨三维（3D）肿瘤结构对深度依赖性注量率、光动力剂量（PDD）和荧光图像的影响。这项工作的目的是将常用的均匀肿瘤密度与非均匀密度进行比较，以确定在理论研究中纳入3D模型的重要性。结果发现，分形3D模型平均能使治疗性辐射的穿透更深，且PDD更高。与等效的平滑模型相比，在所研究的一种分形结构中观察到有效治疗深度增加了1毫米。模拟了宽视野荧光图像，揭示了肿瘤结构与荧光强度外观之间的关系。我们的模型表明，3D肿瘤结构强烈影响治疗光的空间分布、PDD以及表面荧光图像的宽视野外观。
