Rezaei Negar, Amini-Kafiabad Sedigheh, Maghsudlu Mahtab, Abolghasemi Hasan
Department of Research and Education and the, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran.
Department of Hematology, Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine; and the, Tehran, Iran.
Transfusion. 2016 Jul;56(7):1891-8. doi: 10.1111/trf.13660. Epub 2016 Jun 6.
Due to blood screening and blood donor selection, the prevalence of hepatitis C virus (HCV) is expected to be lower among blood donors compared to the general population. The effective control of blood-transmitted infectious diseases should be one of the goals of public health. Thus, this case-control study was conducted to evaluate the risk factors of HCV in a representative sample of blood donors in Iran.
A case-control study was conducted on HCV-negative and on serologically confirmed HCV-positive donors across the country from 2009 to 2013. Univariate logistic regression, multiple logistic regression, and subgroup analyses were performed to assess the risk factors in first-time blood donors (FTs) and repeat blood donors (RDs) independently.
A total of 970 cases and 1542 controls were selected from the cohort of Iranian blood donors registered in the Iran Blood Transfusion Organization. Intravenous (IV) drug abuse (ORFT , 6.42; 95% CI, 3.34-12.34; and ORRD , 27.62; 95% CI, 12.58-60.62), living with an IV drug abuser (ORFT , 3.47; 95% CI, 1.26-9.55; and ORRD , 6.95; 95% CI, 1.54-31.34), prison history (ORFT , 2.4; 95% CI, 1.48-3.88; and ORRD , 2.42; 95% CI, 1.38-4.27), sharing personal razors (ORFT , 2.00; 95% CI, 1.01-3.96; and ORRD , 5.62; 95% CI, 2.65-11.89), and medical exposure (ORFT , 1.97; 95% CI, 1.15-3.37; and ORRD , 2.19; 95% CI, 1.27-3.76) were significant independent risk factors in both types of blood donation.
The findings of this analytic study on HCV exposure in Iranian blood donors conforms to those of international studies. Behavioral and medical factors should be examined in the donor health screening process.
由于血液筛查和献血者选择，与普通人群相比，献血者中丙型肝炎病毒（HCV）的流行率预计较低。有效控制血液传播传染病应是公共卫生的目标之一。因此，本病例对照研究旨在评估伊朗有代表性的献血者样本中HCV的危险因素。
2009年至2013年，对全国HCV阴性和血清学确诊的HCV阳性献血者进行了病例对照研究。分别对首次献血者（FTs）和重复献血者（RDs）进行单因素逻辑回归、多因素逻辑回归和亚组分析，以评估危险因素。
从伊朗输血组织登记的献血者队列中，共选取970例病例和1542例对照。静脉注射毒品（FTs的比值比[OR]，6.42；95%置信区间[CI]，3.34 - 12.34；RDs的OR，27.62；95%CI，12.58 - 60.62）、与静脉注射毒品者共同生活（FTs的OR，3.47；95%CI，1.26 - 9.55；RDs的OR，6.95；95%CI，1.54 - 31.34）、有入狱史（FTs的OR，2.4；95%CI，1.48 - 3.88；RDs的OR，2.42；95%CI，1.38 - 4.27）、共用个人剃须刀（FTs的OR，2.00；95%CI，1.01 - 3.96；RDs的OR，5.62；95%CI，2.65 - 11.89）以及医疗暴露（FTs的OR，1.97；95%CI，1.15 - 3.37；RDs的OR，2.19；95%CI，1.27 - 3.76）在两种献血类型中均为显著的独立危险因素。
这项关于伊朗献血者HCV暴露的分析研究结果与国际研究结果一致。在献血者健康筛查过程中应检查行为和医疗因素。
