Okoh Mercy, Saheeb Birch D, Agbelusi Gbemisola A, Omoregie Osawe Felix
Department of Oral and Maxillofacial Surgery, University of Benin Teaching Hospital, Benin City, Nigeria.
Nig Q J Hosp Med. 2013 Oct-Dec;23(4):251-6.
Orofacial lesions are among the earliest clinical manifestations of HIV infections.
This study to investigate the oral lesions seen in HIV positive women with emphasis on the need for diagnosis of oral lesions by all health workers.
A prospective cross-sectional study of HIV positive women attending the HIV/AIDS clinic (PEPFAR) of the University of Benin Teaching Hospital, Benin-city, Nigeria. The subjects were investigated for the presence of oral lesions, between the period January and March, 2011. The study was approved by the ethics committee of the hospital and a written informed consent was obtained from each subject that participated in the study. Determination of HIV related oral lesions was carried out clinically using the criteria proposed by the ECC/WHO, 1993. P values ≤ 0.05 were considered significant.
A total of 107 HIV/AIDS infected women attending the HIV/AIDS Clinic were examined. The age ranged from 18 to 50 years with mean age of 36 ± 9.2 years. The age group of 21 to 30 was the most affected (n = 36, 33.6%). Sixty-one subjects (57.0%) presented with oral lesions. The most common observed oral lesion was pseudomembranous candidiasis (n = 37, 37.8%); followed by melanotic pigmentation (n = 11, 11.2%) and xerostomia (n = 11, 11.2%). Group 1 oral lesions accounted for 64.3%, group 2 accounted for 30.6%, while group 3 accounted for 5.1%.
Oro-facial lesions are among the earliest clinical manifestations of HIV infection. These were commonly observed in HIV infected Nigerian women. Oral candidiasis the most common oral lesion observed in the series may therefore be used as a clinical indicator of early immunodeficiency associated with HIV.
口腔面部病变是HIV感染最早出现的临床表现之一。
本研究旨在调查HIV阳性女性中的口腔病变，强调所有医护人员对口腔病变进行诊断的必要性。
对尼日利亚贝宁城贝宁大学教学医院HIV/AIDS诊所（PEPFAR）的HIV阳性女性进行一项前瞻性横断面研究。在2011年1月至3月期间，对这些受试者进行口腔病变检查。该研究获得了医院伦理委员会的批准，并获得了每位参与研究的受试者的书面知情同意书。根据1993年ECC/WHO提出的标准，对HIV相关口腔病变进行临床诊断。P值≤0.05被认为具有统计学意义。
共检查了107名就诊于HIV/AIDS诊所的HIV/AIDS感染女性。年龄范围为18至50岁，平均年龄为36±9.2岁。21至30岁年龄组受影响最大（n = 36，33.6%）。61名受试者（57.0%）出现口腔病变。观察到的最常见口腔病变是假膜性念珠菌病（n = 37，37.8%）；其次是黑色素沉着（n = 11，11.2%）和口干症（n = 11，11.2%）。第1组口腔病变占64.3%，第2组占30.6%，而第3组占5.1%。
口腔面部病变是HIV感染最早出现的临床表现之一。这些病变在感染HIV的尼日利亚女性中很常见。因此，该系列中观察到的最常见口腔病变——口腔念珠菌病，可作为与HIV相关的早期免疫缺陷的临床指标。
