Biological Process of Aging, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan.
Curr Neuropharmacol. 2017;15(2):324-331. doi: 10.2174/1570159x14666160607205417.
Oxidative stress and neuroinflammation cause many neurological disorders. Recently, it has been reported that molecular hydrogen (H2) functions as an antioxidant and anti-inflammatory agent. The routes of H2 administration in animal model and human clinical studies are roughly classified into three types, inhalation of H2 gas, drinking H2-dissolved water, and injection of H2-dissolved saline. This review discusses some of the remarkable progress that has been made in the research of H2 use for neurological disorders, such as cerebrovascular diseases, neurodegenerative disorders, and neonatal brain disorders. Although most neurological disorders are currently incurable, these studies suggest the clinical potential of H2 administration for their prevention, treatment, and mitigation. Several of the potential effectors of H2 will also be discussed, including cell signaling molecules and hormones that are responsible for preventing oxidative stress and inflammation. Nevertheless, further investigation will be required to determine the direct target molecule of H2.
氧化应激和神经炎症会导致许多神经紊乱。最近有报道称，氢气（H2）可作为一种抗氧化剂和抗炎剂。在动物模型和人体临床研究中，H2 的给药途径大致可分为三种：吸入 H2 气体、饮用 H2 溶解水和注射 H2 溶解生理盐水。本综述讨论了 H2 在治疗神经紊乱方面的一些显著进展，如脑血管疾病、神经退行性疾病和新生儿脑疾病。尽管目前大多数神经紊乱是无法治愈的，但这些研究表明 H2 给药在预防、治疗和缓解这些疾病方面具有临床潜力。还将讨论 H2 的一些潜在效应因子，包括负责预防氧化应激和炎症的细胞信号分子和激素。然而，仍需要进一步研究以确定 H2 的直接靶分子。
