Nishimaki Kiyomi, Asada Takashi, Ohsawa Ikuroh, Nakajima Etsuko, Ikejima Chiaki, Yokota Takashi, Kamimura Naomi, Ohta Shigeo
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nippon Medical School, 1-396, Kosugimachi, Nakahara-ku, Kawasaki, Kanagawa 211-8533, Japan.
Department of Neuropsychiatry, Institute of Clinical Medicine, University of Tsukuba, 1-1-1, Ten-noudai, Tsukuba, Ibaraki, 305-8577, Japan.
Curr Alzheimer Res. 2018 Mar 14;15(5):482-492. doi: 10.2174/1567205014666171106145017.
Oxidative stress is one of the causative factors in the pathogenesis of neurodegenerative diseases including mild cognitive impairment (MCI) and dementia. We previously reported that molecular hydrogen (H2) acts as a therapeutic and preventive antioxidant.
We assess the effects of drinking H2-water (water infused with H2) on oxidative stress model mice and subjects with MCI.
Transgenic mice expressing a dominant-negative form of aldehyde dehydrogenase 2 were used as a dementia model. The mice with enhanced oxidative stress were allowed to drink H2-water. For a randomized double-blind placebo-controlled clinical study, 73 subjects with MCI drank ~300 mL of H2-water (H2-group) or placebo water (control group) per day, and the Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) scores were determined after 1 year.
In mice, drinking H2-water decreased oxidative stress markers and suppressed the decline of memory impairment and neurodegeneration. Moreover, the mean lifespan in the H2-water group was longer than that of the control group. In MCI subjects, although there was no significant difference between the H2- and control groups in ADAS-cog score after 1 year, carriers of the apolipoprotein E4 (APOE4) genotype in the H2-group were improved significantly on total ADAS-cog score and word recall task score (one of the sub-scores in the ADAS-cog score).
H2-water may have a potential for suppressing dementia in an oxidative stress model and in the APOE4 carriers with MCI.
氧化应激是包括轻度认知障碍（MCI）和痴呆症在内的神经退行性疾病发病机制中的致病因素之一。我们之前报道过，分子氢（H₂）具有治疗和预防抗氧化作用。
我们评估饮用富氢水（溶有H₂的水）对氧化应激模型小鼠和MCI受试者的影响。
将表达显性负性醛脱氢酶2的转基因小鼠用作痴呆模型。让氧化应激增强的小鼠饮用富氢水。在一项随机双盲安慰剂对照临床研究中，73名MCI受试者每天饮用约300 mL富氢水（富氢组）或安慰剂水（对照组），1年后测定阿尔茨海默病评估量表认知子量表（ADAS-cog）评分。
在小鼠中，饮用富氢水可降低氧化应激标志物，并抑制记忆障碍和神经退行性变的衰退。此外，富氢水组的平均寿命长于对照组。在MCI受试者中，虽然1年后富氢组和对照组的ADAS-cog评分无显著差异，但富氢组中载脂蛋白E4（APOE4）基因型携带者的ADAS-cog总分和单词回忆任务评分（ADAS-cog评分中的子评分之一）有显著改善。
富氢水可能具有抑制氧化应激模型和APOE4基因携带者MCI患者痴呆症的潜力。
