Division of Immunology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.
Nat Rev Cancer. 2016 Jul;16(7):431-46. doi: 10.1038/nrc.2016.52. Epub 2016 Jun 10.
Neutrophils are indispensable antagonists of microbial infection and facilitators of wound healing. In the cancer setting, a newfound appreciation for neutrophils has come into view. The traditionally held belief that neutrophils are inert bystanders is being challenged by the recent literature. Emerging evidence indicates that tumours manipulate neutrophils, sometimes early in their differentiation process, to create diverse phenotypic and functional polarization states able to alter tumour behaviour. In this Review, we discuss the involvement of neutrophils in cancer initiation and progression, and their potential as clinical biomarkers and therapeutic targets.
中性粒细胞是微生物感染的不可或缺的拮抗剂，也是伤口愈合的促进剂。在癌症环境中，人们对中性粒细胞有了新的认识。最近的文献挑战了传统观点，即中性粒细胞是惰性的旁观者。新兴证据表明，肿瘤会操纵中性粒细胞，有时在其分化过程的早期就会操纵，以创造多种表型和功能极化状态，从而改变肿瘤的行为。在这篇综述中，我们讨论了中性粒细胞在癌症发生和发展中的作用，以及它们作为临床生物标志物和治疗靶点的潜力。
