Rodríguez-García J L, Carmona-Sánchez R
Escuela de Medicina Universidad Cuauhtémoc, San Luis Potosí, México.
Grupo Médico Médica Arista, San Luis Potosí, México.
Rev Gastroenterol Mex. 2016 Jul-Sep;81(3):126-33. doi: 10.1016/j.rgmx.2016.02.009. Epub 2016 Jun 6.
Helicobacter pylori causes motor, secretory, and inflammatory gastrointestinal disorders and therefore the term "functional" has been questioned when referring to dyspepsia associated with this bacterium. Patients with dyspepsia and Helicobacter pylori infection could have clinical characteristics that differentiate them a priori from those with true functional dyspepsia.
To determine whether there are clinical differences between patients with functional dyspepsia and Helicobacter pylori-associated dyspepsia that enable their a priori identification and to know the prevalence of Helicobacter pylori infection in patients with functional dyspepsia.
A total of 578 patients with dyspepsia with no significant lesions detectable through endoscopy were divided into 2 groups according to the presence of Helicobacter pylori. The clinical characteristics, medical history, comorbidities, and use of health resources were compared between the two groups. A sub-analysis pairing the groups by age and sex in a 1:1 ratio was carried out to reduce bias.
A total of 336 patients infected with Helicobacter pylori were compared with 242 non-infected patients. The prevalence of infection in the patients with dyspeptic symptoms and no endoscopically detectable lesions was 58%. The initial analysis showed that the cases with dyspepsia and Helicobacter pylori infection were more frequently associated with overweight, obesity, high blood pressure, diabetes mellitus, and metabolic syndrome, but the paired analysis nullified all these differences.
The patients with dyspepsia infected with Helicobacter pylori had similar clinical characteristics to the non-infected patients and could not be differentiated a priori. The prevalence of Helicobacter pylori infection in patients with functional dyspepsia was 58% and increased with age.
幽门螺杆菌可引发胃肠道运动、分泌及炎症性疾病，因此，在提及与该细菌相关的消化不良时，“功能性”这一术语受到了质疑。消化不良且感染幽门螺杆菌的患者可能具有一些临床特征，使其在发病前就能与真正的功能性消化不良患者区分开来。
确定功能性消化不良患者与幽门螺杆菌相关性消化不良患者之间是否存在能够使其在发病前得以鉴别的临床差异，并了解功能性消化不良患者中幽门螺杆菌感染的患病率。
共有578例经内镜检查未发现明显病变的消化不良患者，根据是否感染幽门螺杆菌分为两组。比较两组患者的临床特征、病史、合并症及医疗资源使用情况。为减少偏倚，按1:1的年龄和性别比例对两组进行配对亚分析。
共对336例感染幽门螺杆菌的患者与242例未感染患者进行了比较。有消化不良症状且内镜检查未发现病变的患者中，感染率为58%。初步分析显示，消化不良且感染幽门螺杆菌的患者更常伴有超重、肥胖、高血压、糖尿病和代谢综合征，但配对分析消除了所有这些差异。
感染幽门螺杆菌的消化不良患者与未感染患者具有相似的临床特征，无法在发病前进行区分。功能性消化不良患者中幽门螺杆菌感染率为58%，且随年龄增长而升高。
