Quatrini M, Boarino V, Ghidoni A, Baldassarri A R, Bianchi P A, Bardella M T
Cattedra di Gastroenterologia-Istituto di Scienze Mediche, IRCCS-Ospedale Maggiore, Milano, Italy.
J Clin Gastroenterol. 2001 Mar;32(3):215-7. doi: 10.1097/00004836-200103000-00006.
As available data on Helicobacter pylori infection in patients with diabetes are scattered and discordant, we evaluated the prevalence of H. pylori and its relationship to dyspeptic symptoms in adult patients with diabetes and subjects with dyspepsia. H. pylori infection (evaluated using the 13C urea breath test) and dyspeptic symptoms (nausea, bloating, and epigastric distress) were investigated in 71 consecutive diabetic outpatients; the presence of gross lesions, histologic gastritis, and Helicobacter was verified in the patients with a positive urea test who agreed to undergo upper gastrointestinal tract endoscopy. Seventy-one age- and gender-matched subjects with dyspepsia were used as controls. Helicobacter pylori infection was detected in 49 (69%) patients with diabetes and in 33 (46%) subject with dyspepsia (p = 0.007). Helicobacter pylori was present in 27 (77%) of 35 patients with diabetes with dyspeptic symptoms and in 22 (61%) of 36 patients without dyspeptic symptoms. Endoscopy revealed peptic ulcers in 13 of 23 patients; H. pylori infection was histologically confirmed in the gastric antrum of all patients with diabetes, and in the body of the stomach in 74%. The significantly higher prevalence of H. pylori infection in the patients with diabetes may partially explain their dyspeptic symptoms. The high prevalence of H. pylori infection, esophagitis, and peptic ulcers found in our patients with diabetes (with or without dyspepsia) suggests that this population should be considered "at risk" for H. pylori infection and suitable candidates for treatment.
由于糖尿病患者幽门螺杆菌感染的现有数据分散且不一致，我们评估了成年糖尿病患者和消化不良患者中幽门螺杆菌的患病率及其与消化不良症状的关系。对71例连续的糖尿病门诊患者进行了幽门螺杆菌感染（采用13C尿素呼气试验评估）和消化不良症状（恶心、腹胀和上腹部不适）的调查；对尿素试验阳性且同意接受上消化道内镜检查的患者，核实其是否存在肉眼病变、组织学胃炎和幽门螺杆菌。71例年龄和性别匹配的消化不良患者作为对照。49例（69%）糖尿病患者和33例（46%）消化不良患者检测到幽门螺杆菌感染（p = 0.007）。35例有消化不良症状的糖尿病患者中27例（77%）存在幽门螺杆菌，36例无消化不良症状的患者中22例（61%）存在幽门螺杆菌。内镜检查发现23例患者中有13例患有消化性溃疡；所有糖尿病患者胃窦部均经组织学证实有幽门螺杆菌感染，胃体部74%有感染。糖尿病患者中幽门螺杆菌感染率显著较高可能部分解释了他们的消化不良症状。我们的糖尿病患者（有或无消化不良）中幽门螺杆菌感染、食管炎和消化性溃疡的高患病率表明，该人群应被视为幽门螺杆菌感染的“高危”人群，是合适的治疗对象。
