用于检测分枝杆菌的磁性多价海藻糖糖聚合物纳米颗粒
Magnetic Multivalent Trehalose Glycopolymer Nanoparticles for the Detection of Mycobacteria.
作者信息
Chen Xuan, Wu Bin, Jayawardana Kalana W, Hao Nanjing, Jayawardena H Surangi N, Langer Robert, Jaklenec Ana, Yan Mingdi
机构信息
Department of Chemistry, University of Massachusetts, Lowell, MA, 01854, USA.
David H. Koch Institute of Integrative Cancer Research Centre, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
出版信息
Adv Healthc Mater. 2016 Aug;5(16):2007-12. doi: 10.1002/adhm.201600071. Epub 2016 Jun 10.
Abstract
A multivalent trehalose-grafted poly(lactic acid) is synthesized and encapsulated with iron oxide magnetic nanoparticles. The magnetic micelles interact with Mycobacterium smegmatis to form orange clusters. Very little particle interaction is found on Staphylococcus epidermidis 35984 or Escherichia coli ORN 208. The presented new approach to the detection of mycobacteria does not require molecular biology reagents or sophisticated instruments.
摘要
合成了一种多价海藻糖接枝聚乳酸，并将其与氧化铁磁性纳米颗粒封装在一起。磁性胶束与耻垢分枝杆菌相互作用形成橙色簇状物。在表皮葡萄球菌35984或大肠杆菌ORN 208上几乎未发现颗粒相互作用。所提出的检测分枝杆菌的新方法不需要分子生物学试剂或精密仪器。
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