Vinciguerra Daniele, Gelb Madeline B, Maynard Heather D
Department of Chemistry and Biochemistry, University of California, Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California 90095-1569, United States.
California NanoSystems Institute, University of California, Los Angeles, 570 Westwood Plaza, Los Angeles, California 90095-1569, United States.
JACS Au. 2022 Jul 6;2(7):1561-1587. doi: 10.1021/jacsau.2c00309. eCollection 2022 Jul 25.
Trehalose is a naturally occurring, nonreducing disaccharide that is widely used in the biopharmaceutical, food, and cosmetic industries due to its stabilizing and cryoprotective properties. Over the years, scientists have developed methodologies to synthesize linear polymers with trehalose units either in the polymer backbone or as pendant groups. These macromolecules provide unique properties and characteristics, which often outperform trehalose itself. Additionally, numerous reports have focused on the synthesis and formulation of materials based on trehalose, such as nanoparticles, hydrogels, and thermoset networks. Among many applications, these polymers and materials have been used as protein stabilizers, as gene delivery systems, and to prevent amyloid aggregate formation. In this Perspective, recent developments in the synthesis and application of trehalose-based linear polymers, hydrogels, and nanomaterials are discussed, with a focus on utilization in the biomedical field.
海藻糖是一种天然存在的非还原性二糖，因其具有稳定和冷冻保护特性而广泛应用于生物制药、食品和化妆品行业。多年来，科学家们已经开发出各种方法来合成在聚合物主链中或作为侧基含有海藻糖单元的线性聚合物。这些大分子具有独特的性能和特征，其性能往往优于海藻糖本身。此外，大量报道聚焦于基于海藻糖的材料的合成与配方，如纳米颗粒、水凝胶和热固性网络。在众多应用中，这些聚合物和材料已被用作蛋白质稳定剂、基因递送系统以及预防淀粉样蛋白聚集体的形成。在这篇综述中，我们将讨论基于海藻糖的线性聚合物、水凝胶和纳米材料在合成与应用方面的最新进展，重点关注其在生物医学领域的应用。
